FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174328471> ?p ?o ?g. }

• W3174328471 endingPage "1057" @default.
• W3174328471 startingPage "1057" @default.
• W3174328471 abstract "Manganese superoxide dismutase (MnSOD) is a dominant component of the antioxidant defense system in mammalian cells. Since ionizing irradiation induces profound oxidative stress, it was logical to test the effect of overexpression of MnSOD on radioresistance. This task was accomplished by introduction of a transgene for MnSOD into cells in vitro and into organs in vivo, and both paradigms showed clear radioresistance following overexpression. During the course of development and clinical application of using MnSOD as a radioprotector, several prominent observations were made by Larry Oberley, Joel Greenberger, and Michael Epperly which include (1) mitochondrial localization of either manganese superoxide dismutase or copper/zinc SOD was required to provide optimal radiation protection; (2) the time required for optimal expression was 12–18 h, and while acceptable for radiation protection, the time delay was impractical for radiation mitigation; (3) significant increases in intracellular elevation of MnSOD activity were required for effective radioprotection. Lessons learned during the development of MnSOD gene therapy have provided a strategy for delivery of small molecule SOD mimics, which are faster acting and have shown the potential for both radiation protection and mitigation. The purpose of this review is to summarize the current status of using MnSOD-PL and SOD mimetics as radioprotectors and radiomitigators." @default.
• W3174328471 created "2021-07-05" @default.
• W3174328471 creator A5032561470 @default.
• W3174328471 creator A5063266916 @default.
• W3174328471 creator A5078588576 @default.
• W3174328471 date "2021-06-30" @default.
• W3174328471 modified "2023-10-01" @default.
• W3174328471 title "Gene Therapy for Systemic or Organ Specific Delivery of Manganese Superoxide Dismutase" @default.
• W3174328471 cites W1971938662 @default.
• W3174328471 cites W1973857971 @default.
• W3174328471 cites W1981654793 @default.
• W3174328471 cites W1990906371 @default.
• W3174328471 cites W1995538793 @default.
• W3174328471 cites W2005870177 @default.
• W3174328471 cites W2013758383 @default.
• W3174328471 cites W2017165912 @default.
• W3174328471 cites W2019485706 @default.
• W3174328471 cites W2039161420 @default.
• W3174328471 cites W2064475579 @default.
• W3174328471 cites W2069325733 @default.
• W3174328471 cites W2071293670 @default.
• W3174328471 cites W2086415396 @default.
• W3174328471 cites W2093730650 @default.
• W3174328471 cites W2103446053 @default.
• W3174328471 cites W2107516957 @default.
• W3174328471 cites W2112417881 @default.
• W3174328471 cites W2115912875 @default.
• W3174328471 cites W2116808031 @default.
• W3174328471 cites W2119921083 @default.
• W3174328471 cites W2132950999 @default.
• W3174328471 cites W2140731277 @default.
• W3174328471 cites W2147422232 @default.
• W3174328471 cites W2148312119 @default.
• W3174328471 cites W2165166188 @default.
• W3174328471 cites W2166741387 @default.
• W3174328471 cites W2176384617 @default.
• W3174328471 cites W2179043635 @default.
• W3174328471 cites W2196797460 @default.
• W3174328471 cites W2274695480 @default.
• W3174328471 cites W2396095256 @default.
• W3174328471 cites W2544173975 @default.
• W3174328471 cites W2581967109 @default.
• W3174328471 cites W2795128393 @default.
• W3174328471 cites W2953647884 @default.
• W3174328471 cites W2994763742 @default.
• W3174328471 cites W3008945669 @default.
• W3174328471 cites W4237005929 @default.
• W3174328471 doi "https://doi.org/10.3390/antiox10071057" @default.
• W3174328471 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8300724" @default.
• W3174328471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34208819" @default.
• W3174328471 hasPublicationYear "2021" @default.
• W3174328471 type Work @default.
• W3174328471 sameAs 3174328471 @default.
• W3174328471 citedByCount "3" @default.
• W3174328471 countsByYear W31743284712022 @default.
• W3174328471 crossrefType "journal-article" @default.
• W3174328471 hasAuthorship W3174328471A5032561470 @default.
• W3174328471 hasAuthorship W3174328471A5063266916 @default.
• W3174328471 hasAuthorship W3174328471A5078588576 @default.
• W3174328471 hasBestOaLocation W31743284711 @default.
• W3174328471 hasConcept C102230213 @default.
• W3174328471 hasConcept C104317684 @default.
• W3174328471 hasConcept C111337013 @default.
• W3174328471 hasConcept C111599444 @default.
• W3174328471 hasConcept C121332964 @default.
• W3174328471 hasConcept C135983454 @default.
• W3174328471 hasConcept C18231593 @default.
• W3174328471 hasConcept C185544564 @default.
• W3174328471 hasConcept C185592680 @default.
• W3174328471 hasConcept C202751555 @default.
• W3174328471 hasConcept C207001950 @default.
• W3174328471 hasConcept C2775838275 @default.
• W3174328471 hasConcept C2776151105 @default.
• W3174328471 hasConcept C48349386 @default.
• W3174328471 hasConcept C502942594 @default.
• W3174328471 hasConcept C54355233 @default.
• W3174328471 hasConcept C55493867 @default.
• W3174328471 hasConcept C58962609 @default.
• W3174328471 hasConcept C81885089 @default.
• W3174328471 hasConcept C86803240 @default.
• W3174328471 hasConcept C95444343 @default.
• W3174328471 hasConceptScore W3174328471C102230213 @default.
• W3174328471 hasConceptScore W3174328471C104317684 @default.
• W3174328471 hasConceptScore W3174328471C111337013 @default.
• W3174328471 hasConceptScore W3174328471C111599444 @default.
• W3174328471 hasConceptScore W3174328471C121332964 @default.
• W3174328471 hasConceptScore W3174328471C135983454 @default.
• W3174328471 hasConceptScore W3174328471C18231593 @default.
• W3174328471 hasConceptScore W3174328471C185544564 @default.
• W3174328471 hasConceptScore W3174328471C185592680 @default.
• W3174328471 hasConceptScore W3174328471C202751555 @default.
• W3174328471 hasConceptScore W3174328471C207001950 @default.
• W3174328471 hasConceptScore W3174328471C2775838275 @default.
• W3174328471 hasConceptScore W3174328471C2776151105 @default.
• W3174328471 hasConceptScore W3174328471C48349386 @default.
• W3174328471 hasConceptScore W3174328471C502942594 @default.
• W3174328471 hasConceptScore W3174328471C54355233 @default.
• W3174328471 hasConceptScore W3174328471C55493867 @default.

• next