FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174341185> ?p ?o ?g. }

• W3174341185 abstract "The sympathetic nerve activity and arterial blood pressure responses to static muscle contraction are greater in rats with femoral artery ligation, likely due to enhanced ASIC3 expression in thin muscle afferent nerves. The current study was to characterize acid-induced current with activation of ASIC3 in DRG neurons of control rats and rats with 24 hrs of femoral occlusion using whole-cell patch clamp methods. Also, existence of ASIC3 in DRG neurons of thin fiber afferents was examined. The DRG neurons were labeled by injecting the fluorescence tracer DiI into the hindlimb muscles. The data showed that ~90% of current responses evoked by pH 6.7 in DRG neurons are ASIC3-like. The peak current amplitude to pH 6.7 is significantly attenuated with rAPETx2, a specific ASIC3 antagonist. In addition, ASIC3-like current responses to pH 6.7 are seen in small, medium and large size of DRG neurons and the distribution of the size of DRG neurons is similar in both groups. However, the peak current amplitude of DRG neuron response induced by stimulation of ASIC3 is larger in occluded rats than that in control rats. Moreover, the percentage of DRG neurons with ASIC3-like currents is greater after arterial occlusion compared with control. Furthermore, the data showed that femoral occlusion mainly augments expression of ASIC3 within DRG neurons projecting C-fiber afferents. Overall, these data suggest that (1) the majority of current responses to pH 6.7 are ASIC3-like in DRG neurons with nerve endings in the hindlimb muscles; (2) a greater acid-induced current responding to pH 6.7 is developed as the blood supply to the hindlimb is deficient, and (3) increased ASIC3 is largely seen in C-fiber of DRG neurons after the hindlimb ischemia." @default.
• W3174341185 created "2021-07-05" @default.
• W3174341185 creator A5016647517 @default.
• W3174341185 creator A5031153639 @default.
• W3174341185 creator A5046380471 @default.
• W3174341185 date "2012-04-01" @default.
• W3174341185 modified "2023-10-14" @default.
• W3174341185 title "Characterize ASIC3 in Muscle Sensory Neurons with Femoral Artery Occlusion" @default.
• W3174341185 doi "https://doi.org/10.1096/fasebj.26.1_supplement.1087.7" @default.
• W3174341185 hasPublicationYear "2012" @default.
• W3174341185 type Work @default.
• W3174341185 sameAs 3174341185 @default.
• W3174341185 citedByCount "0" @default.
• W3174341185 crossrefType "journal-article" @default.
• W3174341185 hasAuthorship W3174341185A5016647517 @default.
• W3174341185 hasAuthorship W3174341185A5031153639 @default.
• W3174341185 hasAuthorship W3174341185A5046380471 @default.
• W3174341185 hasConcept C105702510 @default.
• W3174341185 hasConcept C126322002 @default.
• W3174341185 hasConcept C164705383 @default.
• W3174341185 hasConcept C169760540 @default.
• W3174341185 hasConcept C2779723990 @default.
• W3174341185 hasConcept C51738704 @default.
• W3174341185 hasConcept C71924100 @default.
• W3174341185 hasConcept C86803240 @default.
• W3174341185 hasConceptScore W3174341185C105702510 @default.
• W3174341185 hasConceptScore W3174341185C126322002 @default.
• W3174341185 hasConceptScore W3174341185C164705383 @default.
• W3174341185 hasConceptScore W3174341185C169760540 @default.
• W3174341185 hasConceptScore W3174341185C2779723990 @default.
• W3174341185 hasConceptScore W3174341185C51738704 @default.
• W3174341185 hasConceptScore W3174341185C71924100 @default.
• W3174341185 hasConceptScore W3174341185C86803240 @default.
• W3174341185 hasIssue "S1" @default.
• W3174341185 hasLocation W31743411851 @default.
• W3174341185 hasOpenAccess W3174341185 @default.
• W3174341185 hasPrimaryLocation W31743411851 @default.
• W3174341185 hasRelatedWork W1982768582 @default.
• W3174341185 hasRelatedWork W1983403944 @default.
• W3174341185 hasRelatedWork W2011347913 @default.
• W3174341185 hasRelatedWork W2016729603 @default.
• W3174341185 hasRelatedWork W2049397185 @default.
• W3174341185 hasRelatedWork W2074833529 @default.
• W3174341185 hasRelatedWork W2159512267 @default.
• W3174341185 hasRelatedWork W2304633692 @default.
• W3174341185 hasRelatedWork W2399063111 @default.
• W3174341185 hasRelatedWork W243143012 @default.
• W3174341185 hasVolume "26" @default.
• W3174341185 isParatext "false" @default.
• W3174341185 isRetracted "false" @default.
• W3174341185 magId "3174341185" @default.
• W3174341185 workType "article" @default.