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- W3174355461 abstract "Muscle loss and metabolic changes occur with disuse [i.e. bed rest (BR)]. We investigated the metabolic profile after 28 days of BR with energy deficit in individuals randomized to resistance exercise with amino acid supplementation (RT, n=24) or amino acid supplementation alone (AA, n=7). We hypothesized that BR would lead to a metabolically unhealthy profile defined by: increased circulating tumor necrosis factor (TNF)-α, decreased circulating insulin-like-growth-factor (IGF)-1, decreased HDL-cholesterol, decreased normal density muscle (NDM) and increased low density muscle (LDM; measured by mid-thigh computerized tomography). We found a shift toward a metabolically unhealthy profile after BR (compared to baseline) in both groups as shown by decreased HDL levels (AA: 39±4 →32±2 mg/dL, RT: 39±1 →32±1 mg/dL; p<0.001) and LDM (AA: 27±4 →22±3 cm2, RT: 28±2 → 23±2 cm2; p<0.001). A healthier metabolic profile was maintained with exercise, including NDM (AA: 124±6 → 110±5 cm2, RT: 132±3 → 131±4 cm2; p<0.001, time-by-group); although, exercise did not completely alleviate the unfavourable metabolic changes seen with BR. Interestingly, both groups had increased plasma IGF-1 levels (AA: 168±22 → 213±20ng/mL, RT: 180±10 → 219±13 ng/mL; p<0.001) and neither group showed TNFα changes (p>;0.05). We conclude that RT can partially offset the metabolic complications of BR. Support: NSBRI-NPFR00301 & GCRC M01 RR00" @default.
- W3174355461 created "2021-07-05" @default.
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- W3174355461 date "2013-04-01" @default.
- W3174355461 modified "2023-09-23" @default.
- W3174355461 title "Influence of exercise during 28 days of bed rest with energy deficit and amino acid supplementation on metabolic profile" @default.
- W3174355461 doi "https://doi.org/10.1096/fasebj.27.1_supplement.712.6" @default.
- W3174355461 hasPublicationYear "2013" @default.
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