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- W3174373442 abstract "We have investigated the role of the endogenous anti-inflammatory lipoxin LXA4 in modulating Cl− secretion and Na+ absorption, airway surface liquid height (ASLh) and ciliary beat frequency (CBF) in CF and non-CF bronchial epithelia. CF (CuFi-1) and non-CF (NuLi-1) bronchial epithelial cell lines were grown under an air-surface liquid interface into well-differentiated epithelia. ASLh and CBF were measured using confocal fluorescence microscopy and ion transport using patch-clamp and short-circuit current techniques. LXA4 (1nM) treatment for 15 minutes, increased ASLh by 47.5±0.5 % and 103.0±3.0 % in NuLi and CuFi epithelia respectively (P<0.001, n=18). The stimulatory effect of LXA4 on ASLh was sustained over 24 hours in the CF epithelia and was inhibited by the following pre-treatments: bumetanide, amiloride, Boc-2 (LXA4 receptor antagonist), reactive blue (P2Y receptor antagonist) and extracellular hexokinase (ATP hydrolysis). LXA4 stimulated CBF, intracellular Ca2+ mobilization, Cl− secretion and inhibited Na+ absorption in the CF epithelia. These effects of lipoxin involving the FPR2 receptor, apical ATP release, purinoreceptor activation, inhibition of Na+ absorption and stimulation of Cl− secretion to enhance airway surface liquid dynamics open up a new therapeutic avenue to promote mucociliary clearance in cystic fibrosis airways." @default.
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- W3174373442 date "2011-04-01" @default.
- W3174373442 modified "2023-10-16" @default.
- W3174373442 title "Regulation of ion transporters and airway surface dynamics by lipoxin in cystic fibrosis bronchial epithelium" @default.
- W3174373442 doi "https://doi.org/10.1096/fasebj.25.1_supplement.1038.9" @default.
- W3174373442 hasPublicationYear "2011" @default.
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