FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174384189> ?p ?o ?g. }

• W3174384189 abstract "The primary function of skeletal muscle (SKM) is to implement locomotion, but muscles also serve other important functions such as generating heat through shivering (and non-shivering), which involves continuous contraction and relaxation. Arctic ground squirrels (AGS), Spermophilus parryii, undergo extreme temperature fluctuations during the hibernating season (body temperature as low as −3 °C), where they mostly remain physically inactive. Despite prolonged periods of immobilization and starvation during hibernation, AGS and other hibernating mammals are protected from muscle atrophy, weakness, and loss of protein content. In contrast, non-hibernators (like Sprague Dawley (SD)) are susceptible to muscle atrophy, rhabdomyolysis and myotonia etc. due to muscle inactivity. To our knowledge no study has shown the effects of temperature on muscle contractile function compared between hibernators and non-hibernators. We hypothesized that hibernators maintain their muscle contractile function and performance, over a wider temperature range compared to non-hibernators. We characterized and compared the alterations in SKM contractile function during hypothermic temperature stress. An Ex vivo functional assay was implemented, utilizing a tissue organ bath system (TOBS) and involved extracting diaphragm muscle from both AGS and SD, create strips made from SKM while keeping it in oxygenated Ringers solution. Following transfer of strips to respective organ bath chambers, muscles were exposed to 37°C for 30 mins (control/initial phase), 30 mins of experimental temperature (4 °C; 15 °C; 25 °C and 37 °C), and then finally back to 37 °C for 30min (recovery phase). Real time data (contractile function via force transducer) was recorded from the TOBS using LabChart Pro, and a force frequency curve was plotted. Preliminary data suggest that SKM of both hibernators and non-hibernators during the experimental hypothermia phase showed suppressed (and slow) contractile function in both species, with the lowest force values at 4 °C. However, during the recovery phase AGS displayed higher functional recovery from hypothermic conditions compared to SD. This evidence supports the fact that SKM of hibernating animals is expected to have higher adaptability and increased contractile functional recovery from thermal stress compared to SKM of non-hibernating animals. Support or Funding Information This work was supported by the INBRE IDeA Faculty Pilot Grant (University of Alaska Fairbanks ) from NIH NIGMS grant number P20GM103395. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal." @default.
• W3174384189 created "2021-07-05" @default.
• W3174384189 creator A5039372321 @default.
• W3174384189 creator A5047935276 @default.
• W3174384189 creator A5051285231 @default.
• W3174384189 creator A5090127429 @default.
• W3174384189 date "2019-04-01" @default.
• W3174384189 modified "2023-09-26" @default.
• W3174384189 title "Effects of Hypothermia on Skeletal Muscle Contractile Function: Comparison between Hibernators and Non‐hibernators" @default.
• W3174384189 doi "https://doi.org/10.1096/fasebj.2019.33.1_supplement.868.34" @default.
• W3174384189 hasPublicationYear "2019" @default.
• W3174384189 type Work @default.
• W3174384189 sameAs 3174384189 @default.
• W3174384189 citedByCount "0" @default.
• W3174384189 crossrefType "journal-article" @default.
• W3174384189 hasAuthorship W3174384189A5039372321 @default.
• W3174384189 hasAuthorship W3174384189A5047935276 @default.
• W3174384189 hasAuthorship W3174384189A5051285231 @default.
• W3174384189 hasAuthorship W3174384189A5090127429 @default.
• W3174384189 hasConcept C100564792 @default.
• W3174384189 hasConcept C105702510 @default.
• W3174384189 hasConcept C11413529 @default.
• W3174384189 hasConcept C119865680 @default.
• W3174384189 hasConcept C126322002 @default.
• W3174384189 hasConcept C134018914 @default.
• W3174384189 hasConcept C185592680 @default.
• W3174384189 hasConcept C2776050358 @default.
• W3174384189 hasConcept C2777390192 @default.
• W3174384189 hasConcept C2779379848 @default.
• W3174384189 hasConcept C2779959927 @default.
• W3174384189 hasConcept C2781172350 @default.
• W3174384189 hasConcept C2781258859 @default.
• W3174384189 hasConcept C41008148 @default.
• W3174384189 hasConcept C42407357 @default.
• W3174384189 hasConcept C48103436 @default.
• W3174384189 hasConcept C66538056 @default.
• W3174384189 hasConcept C71924100 @default.
• W3174384189 hasConcept C86803240 @default.
• W3174384189 hasConceptScore W3174384189C100564792 @default.
• W3174384189 hasConceptScore W3174384189C105702510 @default.
• W3174384189 hasConceptScore W3174384189C11413529 @default.
• W3174384189 hasConceptScore W3174384189C119865680 @default.
• W3174384189 hasConceptScore W3174384189C126322002 @default.
• W3174384189 hasConceptScore W3174384189C134018914 @default.
• W3174384189 hasConceptScore W3174384189C185592680 @default.
• W3174384189 hasConceptScore W3174384189C2776050358 @default.
• W3174384189 hasConceptScore W3174384189C2777390192 @default.
• W3174384189 hasConceptScore W3174384189C2779379848 @default.
• W3174384189 hasConceptScore W3174384189C2779959927 @default.
• W3174384189 hasConceptScore W3174384189C2781172350 @default.
• W3174384189 hasConceptScore W3174384189C2781258859 @default.
• W3174384189 hasConceptScore W3174384189C41008148 @default.
• W3174384189 hasConceptScore W3174384189C42407357 @default.
• W3174384189 hasConceptScore W3174384189C48103436 @default.
• W3174384189 hasConceptScore W3174384189C66538056 @default.
• W3174384189 hasConceptScore W3174384189C71924100 @default.
• W3174384189 hasConceptScore W3174384189C86803240 @default.
• W3174384189 hasFunder F4320313638 @default.
• W3174384189 hasFunder F4320337354 @default.
• W3174384189 hasIssue "S1" @default.
• W3174384189 hasLocation W31743841891 @default.
• W3174384189 hasOpenAccess W3174384189 @default.
• W3174384189 hasPrimaryLocation W31743841891 @default.
• W3174384189 hasRelatedWork W1974568996 @default.
• W3174384189 hasRelatedWork W1992839998 @default.
• W3174384189 hasRelatedWork W2056064046 @default.
• W3174384189 hasRelatedWork W2309978229 @default.
• W3174384189 hasRelatedWork W2323125487 @default.
• W3174384189 hasRelatedWork W2404390522 @default.
• W3174384189 hasRelatedWork W2413777875 @default.
• W3174384189 hasRelatedWork W2436585728 @default.
• W3174384189 hasRelatedWork W2463478234 @default.
• W3174384189 hasRelatedWork W2903003156 @default.
• W3174384189 hasVolume "33" @default.
• W3174384189 isParatext "false" @default.
• W3174384189 isRetracted "false" @default.
• W3174384189 magId "3174384189" @default.
• W3174384189 workType "article" @default.