FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174397890> ?p ?o ?g. }

• W3174397890 endingPage "11384" @default.
• W3174397890 startingPage "11369" @default.
• W3174397890 abstract "MicroRNAs (miRNAs), a recently discovered class of noncoding RNAs, play pivotal roles in regulating fundamental biological processes by suppressing the expression of target genes. Aberrant miRNA expression is commonly correlated with human diseases, including cancers. Anti-miRNA oligonucleotides provide an innovative therapeutic strategy for silencing disease-associated miRNAs. However, the clinical application of anti-miRNA therapy has been limited by formulation challenges and physiological delivery barriers. Here, to provide the safe and effective tumor-targeted delivery of anti-miRNAs, we designed carrier-free maleimide-functionalized anti-miRNAs (MI-Anti-miRNAs) that enable “piggybacking” onto albumin in vivo. These functionalized MI-Anti-miRNAs covalently bind to cysteine-34 of endogenous albumin within minutes. In addition to resulting in a markedly extended blood circulation lifetime, this strategy allows MI-Anti-miRNAs to “hitchhike” to the tumor site. Importantly, in situ-generated albumin-Anti-miRNAs are capable of intracellularly internalizing highly negatively charged anti-miRNA molecules and knocking down target miRNAs. In particular, MI-Anti-miRNAs that targeted miRNA-21, which is involved in tumor initiation, progression, invasion, and metastasis in several types of cancer, successfully repressed miRNA-21 activity, resulting in a superior antitumor activity in both solid and metastatic tumor models without causing systemic toxicity. This endogenous albumin-piggybacking approach using MI-Anti-miRNAs provides a simple and broadly applicable platform strategy for the systemic delivery of anti-miRNA therapeutics." @default.
• W3174397890 created "2021-07-05" @default.
• W3174397890 creator A5006855296 @default.
• W3174397890 creator A5024068067 @default.
• W3174397890 creator A5026852861 @default.
• W3174397890 creator A5031417330 @default.
• W3174397890 creator A5038056256 @default.
• W3174397890 creator A5042165953 @default.
• W3174397890 creator A5056431102 @default.
• W3174397890 creator A5068749217 @default.
• W3174397890 creator A5073866582 @default.
• W3174397890 creator A5087972351 @default.
• W3174397890 date "2021-06-30" @default.
• W3174397890 modified "2023-10-17" @default.
• W3174397890 title "A Trojan-Horse Strategy by <i>In Situ</i> Piggybacking onto Endogenous Albumin for Tumor-Specific Neutralization of Oncogenic MicroRNA" @default.
• W3174397890 cites W1205458192 @default.
• W3174397890 cites W1545336725 @default.
• W3174397890 cites W1576261436 @default.
• W3174397890 cites W1866852956 @default.
• W3174397890 cites W1885174764 @default.
• W3174397890 cites W1966868778 @default.
• W3174397890 cites W1966881634 @default.
• W3174397890 cites W1968128233 @default.
• W3174397890 cites W1969900070 @default.
• W3174397890 cites W1992031451 @default.
• W3174397890 cites W1992885568 @default.
• W3174397890 cites W2002815709 @default.
• W3174397890 cites W2014235909 @default.
• W3174397890 cites W2018956144 @default.
• W3174397890 cites W2019416119 @default.
• W3174397890 cites W2028777474 @default.
• W3174397890 cites W2040851473 @default.
• W3174397890 cites W2042812307 @default.
• W3174397890 cites W2042968293 @default.
• W3174397890 cites W2043948526 @default.
• W3174397890 cites W2051849794 @default.
• W3174397890 cites W2058328925 @default.
• W3174397890 cites W2059310361 @default.
• W3174397890 cites W2061452886 @default.
• W3174397890 cites W2066742760 @default.
• W3174397890 cites W2070003597 @default.
• W3174397890 cites W2075232308 @default.
• W3174397890 cites W2084527701 @default.
• W3174397890 cites W2085056486 @default.
• W3174397890 cites W2090163359 @default.
• W3174397890 cites W2097617161 @default.
• W3174397890 cites W2104373981 @default.
• W3174397890 cites W2109754687 @default.
• W3174397890 cites W2114125706 @default.
• W3174397890 cites W2117616142 @default.
• W3174397890 cites W2127401827 @default.
• W3174397890 cites W2129932149 @default.
• W3174397890 cites W2138664009 @default.
• W3174397890 cites W2155765426 @default.
• W3174397890 cites W2159767268 @default.
• W3174397890 cites W2161693225 @default.
• W3174397890 cites W2171296186 @default.
• W3174397890 cites W2216377839 @default.
• W3174397890 cites W2271213890 @default.
• W3174397890 cites W2338940124 @default.
• W3174397890 cites W2411581583 @default.
• W3174397890 cites W2411706862 @default.
• W3174397890 cites W2414897366 @default.
• W3174397890 cites W2527231434 @default.
• W3174397890 cites W2738523285 @default.
• W3174397890 cites W2755462565 @default.
• W3174397890 cites W2799526435 @default.
• W3174397890 cites W2883860383 @default.
• W3174397890 cites W2887050230 @default.
• W3174397890 cites W2901070929 @default.
• W3174397890 cites W2909365182 @default.
• W3174397890 cites W2911658342 @default.
• W3174397890 cites W2951167623 @default.
• W3174397890 cites W2982394705 @default.
• W3174397890 cites W3025632863 @default.
• W3174397890 cites W4211146992 @default.
• W3174397890 doi "https://doi.org/10.1021/acsnano.1c00799" @default.
• W3174397890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34191497" @default.
• W3174397890 hasPublicationYear "2021" @default.
• W3174397890 type Work @default.
• W3174397890 sameAs 3174397890 @default.
• W3174397890 citedByCount "11" @default.
• W3174397890 countsByYear W31743978902022 @default.
• W3174397890 countsByYear W31743978902023 @default.
• W3174397890 crossrefType "journal-article" @default.
• W3174397890 hasAuthorship W3174397890A5006855296 @default.
• W3174397890 hasAuthorship W3174397890A5024068067 @default.
• W3174397890 hasAuthorship W3174397890A5026852861 @default.
• W3174397890 hasAuthorship W3174397890A5031417330 @default.
• W3174397890 hasAuthorship W3174397890A5038056256 @default.
• W3174397890 hasAuthorship W3174397890A5042165953 @default.
• W3174397890 hasAuthorship W3174397890A5056431102 @default.
• W3174397890 hasAuthorship W3174397890A5068749217 @default.
• W3174397890 hasAuthorship W3174397890A5073866582 @default.
• W3174397890 hasAuthorship W3174397890A5087972351 @default.
• W3174397890 hasConcept C104317684 @default.
• W3174397890 hasConcept C119056186 @default.
• W3174397890 hasConcept C145059251 @default.

• next