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• W3174409620 abstract "Both mathematical models and biological model systems stand as tractable representations of complex biological systems or behaviors. They facilitate research and provide insights, and they can describe general rules. Models that represent biological processes or formalize general hypotheses are essential to any broad understanding. Mathematical or biological models necessarily omit details of the natural systems and thus may ultimately be incorrect representations. A key challenge is that tractability requires relatively simple models but simplification can result in models that are incorrect in their qualitative, broad implications if the abstracted details matter. Our paper discusses this tension, and how we can improve our inferences from models. We advocate for further efforts dedicated to model development, improvement, and acceptance by the scientific community, all of which may necessitate a more explicit discussion of the purpose and power of models. We argue that models should play a central role in reintegrating biology as a way to test our integrated understanding of how molecules, cells, organs, organisms, populations, and ecosystems function." @default.
• W3174409620 created "2021-07-05" @default.
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• W3174409620 date "2021-06-23" @default.
• W3174409620 modified "2023-10-16" @default.
• W3174409620 title "How Can We Fully Realize the Potential of Mathematical and Biological Models to Reintegrate Biology?" @default.
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• W3174409620 doi "https://doi.org/10.1093/icb/icab142" @default.
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• W3174409620 hasPublicationYear "2021" @default.
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