Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174415462> ?p ?o ?g. }
- W3174415462 abstract "The adenosine monophosphate (AMP)–activated protein kinase (AMPK) was initially identified as an enzyme acting as an “energy sensor” in maintaining energy homeostasis via serine/threonine phosphorylation when low cellular adenosine triphosphate (ATP) level was sensed. AMPK participates in catabolic and anabolic processes at the molecular and cellular levels and is involved in appetite-regulating circuit in the hypothalamus. AMPK signaling also modulates energy metabolism in organs such as adipose tissue, brain, muscle, and heart, which are highly dependent on energy consumption via adjusting the AMP/ADP:ATP ratio. In clinics, biguanides and thiazolidinediones are prescribed to patients with metabolic disorders through activating AMPK signaling and inhibiting complex I in the mitochondria, leading to a reduction in mitochondrial respiration and elevated ATP production. The role of AMPK in mediating skeletal development and related diseases remains obscure. In this review, in addition to discuss the emerging advances of AMPK studies in energy control, we will also illustrate current discoveries of AMPK in chondrocyte homeostasis, osteoarthritis (OA) development, and the signaling interaction of AMPK with other pathways, such as mTOR (mechanistic target of rapamycin), Wnt, and NF-κB (nuclear factor κB) under OA condition." @default.
- W3174415462 created "2021-07-05" @default.
- W3174415462 creator A5005689660 @default.
- W3174415462 creator A5006349825 @default.
- W3174415462 creator A5013779064 @default.
- W3174415462 creator A5029946717 @default.
- W3174415462 creator A5031574868 @default.
- W3174415462 creator A5068419450 @default.
- W3174415462 creator A5070444582 @default.
- W3174415462 creator A5078810727 @default.
- W3174415462 date "2021-06-22" @default.
- W3174415462 modified "2023-09-26" @default.
- W3174415462 title "AMPK Signaling in Energy Control, Cartilage Biology, and Osteoarthritis" @default.
- W3174415462 cites W1522419023 @default.
- W3174415462 cites W1552576542 @default.
- W3174415462 cites W1627585603 @default.
- W3174415462 cites W1874251201 @default.
- W3174415462 cites W1899997617 @default.
- W3174415462 cites W1943677324 @default.
- W3174415462 cites W1968423702 @default.
- W3174415462 cites W1970098913 @default.
- W3174415462 cites W1970205234 @default.
- W3174415462 cites W1970923613 @default.
- W3174415462 cites W1971664778 @default.
- W3174415462 cites W1975843279 @default.
- W3174415462 cites W1984328128 @default.
- W3174415462 cites W1988360066 @default.
- W3174415462 cites W1990970592 @default.
- W3174415462 cites W2001568034 @default.
- W3174415462 cites W2002531640 @default.
- W3174415462 cites W2005508370 @default.
- W3174415462 cites W2007096529 @default.
- W3174415462 cites W2015454275 @default.
- W3174415462 cites W2017829233 @default.
- W3174415462 cites W2021904780 @default.
- W3174415462 cites W2025366015 @default.
- W3174415462 cites W2026026508 @default.
- W3174415462 cites W2028429796 @default.
- W3174415462 cites W2029148411 @default.
- W3174415462 cites W2030655863 @default.
- W3174415462 cites W2035737535 @default.
- W3174415462 cites W2036179692 @default.
- W3174415462 cites W2041141449 @default.
- W3174415462 cites W2045791566 @default.
- W3174415462 cites W2051337752 @default.
- W3174415462 cites W2051962629 @default.
- W3174415462 cites W2053003892 @default.
- W3174415462 cites W2056723985 @default.
- W3174415462 cites W2058138221 @default.
- W3174415462 cites W2059724105 @default.
- W3174415462 cites W2068246227 @default.
- W3174415462 cites W2073882423 @default.
- W3174415462 cites W2077008849 @default.
- W3174415462 cites W2078060668 @default.
- W3174415462 cites W2079439744 @default.
- W3174415462 cites W2081920342 @default.
- W3174415462 cites W2083482485 @default.
- W3174415462 cites W2085057937 @default.
- W3174415462 cites W2086405452 @default.
- W3174415462 cites W2088437980 @default.
- W3174415462 cites W2089477557 @default.
- W3174415462 cites W2091557482 @default.
- W3174415462 cites W2092130336 @default.
- W3174415462 cites W2101049975 @default.
- W3174415462 cites W2110005130 @default.
- W3174415462 cites W2111322904 @default.
- W3174415462 cites W2111334968 @default.
- W3174415462 cites W2111413580 @default.
- W3174415462 cites W2118733706 @default.
- W3174415462 cites W2118819459 @default.
- W3174415462 cites W2120774490 @default.
- W3174415462 cites W2125053662 @default.
- W3174415462 cites W2126181510 @default.
- W3174415462 cites W2128001125 @default.
- W3174415462 cites W2129531706 @default.
- W3174415462 cites W2130471928 @default.
- W3174415462 cites W2131456542 @default.
- W3174415462 cites W2133518164 @default.
- W3174415462 cites W2135122709 @default.
- W3174415462 cites W2135424721 @default.
- W3174415462 cites W2139860035 @default.
- W3174415462 cites W2144907410 @default.
- W3174415462 cites W2145348581 @default.
- W3174415462 cites W2149079606 @default.
- W3174415462 cites W2149085285 @default.
- W3174415462 cites W2150551377 @default.
- W3174415462 cites W2150964537 @default.
- W3174415462 cites W2156512494 @default.
- W3174415462 cites W2156620354 @default.
- W3174415462 cites W2163710303 @default.
- W3174415462 cites W2164403708 @default.
- W3174415462 cites W2336720803 @default.
- W3174415462 cites W2339790478 @default.
- W3174415462 cites W2402553346 @default.
- W3174415462 cites W2412284138 @default.
- W3174415462 cites W2473668993 @default.
- W3174415462 cites W2521511481 @default.
- W3174415462 cites W2562922262 @default.
- W3174415462 cites W2574647359 @default.
- W3174415462 cites W2596302024 @default.