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- W3174441830 abstract "Abstract The treatment of chronic bacterial infections by phages has shown promise in combating antimicrobial resistance. A typical phage particle is at least an order of magnitude larger than an antibiotic molecule. Hence, phages diffuse slower than antibiotics, and can also get trapped in the polymeric mesh of biofilm matrix. By tracking fluorescently labeled lambda phages that do not infect Capnocytophaga gingivalis , a bacterium abundant in the human oral microbiota, we demonstrate active phage transportation by a C. gingivalis swarm. As a result, the rate of disruption of the prey of lambda phage i.e., an Escherichia coli colony, increases 10 times. C. gingivalis drills tunnels within a curli fiber containing E. coli biofilm and increase the efficiency of phage penetration. This provides evidence for a novel mechanism of phage-bacterial warfare." @default.
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- W3174441830 date "2021-06-25" @default.
- W3174441830 modified "2023-09-27" @default.
- W3174441830 title "Bacterial swarm-mediated phage transportation disrupts a biofilm inherently protected from phage penetration" @default.
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- W3174441830 doi "https://doi.org/10.1101/2021.06.25.449910" @default.
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