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- W3174443105 abstract "Ventricular muscle cells of adult mammals are terminally differentiated cells that lack regenerative capability. The goal of this study is to induce myocardial regeneration by using myogenic cardiac fibroblasts to replace, repair, maintain, and enhance the cardiac function of an injured heart. Mongrel dogs (18) were randomly assigned into three groups (n=6/group) to have myocardial infarction (MI), MI + autologous cardiac fibroblasts, and MI + myogenic autologous cardiac fibroblasts. Cardiac fibroblasts were isolated from a biopsy sample of the heart after enzymatic treatment and proliferated into significant quantity in culture. Myogenic conversion was induced by 0.3 mM of 5-aza-2′-deoxycytidine treatment in culture 3 days before usage. Myogenic conversion of the treated cardiac fibroblasts was documented by the formation of multinucleated myotubes in differentiation medium. A dramatic reduction of scar area (11 ± 2 vs. 23 ± 4) replaced by viable muscle tissue and a significant increase in % thickening fraction (4.1 ± 0.6 vs. −0.6 ± 0.5) were observed at six weeks after implantation of autologous myogenic cardiac fibroblasts as compared to the other groups. Autologous cardiac fibroblasts did not produce any significant changes as compared to the MI group (injected with serum free culture medium). These results suggested that intra-coronary infusion or intra-myocardial injection of 5-aza-2′-deoxycytidine into the myocardial infraction could be used to induce myocardial regeneration by myogenic transdifferentiation of the existing cardiac fibroblasts. Supported by NIH grant HL72138 and AHA grant 0255009B" @default.
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- W3174443105 date "2006-03-01" @default.
- W3174443105 modified "2023-10-16" @default.
- W3174443105 title "Myogenic Transdifferentiation of Autologous Cardiac Fibroblasts" @default.
- W3174443105 doi "https://doi.org/10.1096/fasebj.20.4.a315-c" @default.
- W3174443105 hasPublicationYear "2006" @default.
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