Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174443700> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W3174443700 abstract "Preeclampsia (PreE) results from an impaired vascular remodeling of the placental spiral arteries. Recent data suggests cytochromeP450 (CYP450) vasoactive eicosanoids in the etiology of the disease. Therefore, we investigated whether alterations in the profile of arachidonic acid (AA) metabolites of the CYP450 pathway contribute to the impaired vascular remodeling in preeclampsia. To this end, we isolated microsomes from placental vessels of normal pregnant (NP) and PreE women and CYP450 enzyme activity was determined by HPLC/mass spectrometry. In addition, the proliferative actions of 20-HETE, a major CYP450 metabolite were investigated in an in vivo model of trophoblast syncytialisation. Placental vascular microsomes from PreE women displayed a significant increase in 20-HETE production relative to NP women (0.192±0.04 vs 0.119±0.06 pg/min/mg, p<0.05). 15-HETE (74±8 vs 43±11 pmol/min/mg), 12-HETE (70±20 vs 27±7 pmol/min/mg, p<0.05), and total HETE production (287±61 vs 170±44 pmol/min/mg) were also increased in PreE compared to NP. Incubation of BeWo cells with 20-HETE (10nM; 100nM; 1uM) displayed an increase in cell proliferation, while inhibition of 20-HETE with 17-ODYA (10uM) and HET0016 (1nM) displayed a 10% and 75% inhibition. Thus, increases in 20-HETE production promote, while inhibition of 20-HETE reduces proliferation of trophoblasts in vitro and may contribute to the altered trophoblast invasion and vascular remodeling in PreE." @default.
- W3174443700 created "2021-07-05" @default.
- W3174443700 creator A5006634903 @default.
- W3174443700 creator A5013151919 @default.
- W3174443700 creator A5013898497 @default.
- W3174443700 date "2015-04-01" @default.
- W3174443700 modified "2023-10-16" @default.
- W3174443700 title "Alterations in Placental Eicosanoid Production Contribute to Impaired Vascular Remodeling in Preeclampsia" @default.
- W3174443700 doi "https://doi.org/10.1096/fasebj.29.1_supplement.967.8" @default.
- W3174443700 hasPublicationYear "2015" @default.
- W3174443700 type Work @default.
- W3174443700 sameAs 3174443700 @default.
- W3174443700 citedByCount "0" @default.
- W3174443700 crossrefType "journal-article" @default.
- W3174443700 hasAuthorship W3174443700A5006634903 @default.
- W3174443700 hasAuthorship W3174443700A5013151919 @default.
- W3174443700 hasAuthorship W3174443700A5013898497 @default.
- W3174443700 hasConcept C126322002 @default.
- W3174443700 hasConcept C134018914 @default.
- W3174443700 hasConcept C172680121 @default.
- W3174443700 hasConcept C181199279 @default.
- W3174443700 hasConcept C185592680 @default.
- W3174443700 hasConcept C2776352991 @default.
- W3174443700 hasConcept C2776953305 @default.
- W3174443700 hasConcept C2777218350 @default.
- W3174443700 hasConcept C2777477808 @default.
- W3174443700 hasConcept C2777495146 @default.
- W3174443700 hasConcept C2778078955 @default.
- W3174443700 hasConcept C2779234561 @default.
- W3174443700 hasConcept C2780771523 @default.
- W3174443700 hasConcept C54355233 @default.
- W3174443700 hasConcept C55493867 @default.
- W3174443700 hasConcept C71924100 @default.
- W3174443700 hasConcept C86803240 @default.
- W3174443700 hasConceptScore W3174443700C126322002 @default.
- W3174443700 hasConceptScore W3174443700C134018914 @default.
- W3174443700 hasConceptScore W3174443700C172680121 @default.
- W3174443700 hasConceptScore W3174443700C181199279 @default.
- W3174443700 hasConceptScore W3174443700C185592680 @default.
- W3174443700 hasConceptScore W3174443700C2776352991 @default.
- W3174443700 hasConceptScore W3174443700C2776953305 @default.
- W3174443700 hasConceptScore W3174443700C2777218350 @default.
- W3174443700 hasConceptScore W3174443700C2777477808 @default.
- W3174443700 hasConceptScore W3174443700C2777495146 @default.
- W3174443700 hasConceptScore W3174443700C2778078955 @default.
- W3174443700 hasConceptScore W3174443700C2779234561 @default.
- W3174443700 hasConceptScore W3174443700C2780771523 @default.
- W3174443700 hasConceptScore W3174443700C54355233 @default.
- W3174443700 hasConceptScore W3174443700C55493867 @default.
- W3174443700 hasConceptScore W3174443700C71924100 @default.
- W3174443700 hasConceptScore W3174443700C86803240 @default.
- W3174443700 hasIssue "S1" @default.
- W3174443700 hasLocation W31744437001 @default.
- W3174443700 hasOpenAccess W3174443700 @default.
- W3174443700 hasPrimaryLocation W31744437001 @default.
- W3174443700 hasRelatedWork W1570638334 @default.
- W3174443700 hasRelatedWork W1586415450 @default.
- W3174443700 hasRelatedWork W2014496137 @default.
- W3174443700 hasRelatedWork W2037611414 @default.
- W3174443700 hasRelatedWork W2098038892 @default.
- W3174443700 hasRelatedWork W2288484453 @default.
- W3174443700 hasRelatedWork W2396301033 @default.
- W3174443700 hasRelatedWork W2759789551 @default.
- W3174443700 hasRelatedWork W2789908952 @default.
- W3174443700 hasRelatedWork W2801807507 @default.
- W3174443700 hasVolume "29" @default.
- W3174443700 isParatext "false" @default.
- W3174443700 isRetracted "false" @default.
- W3174443700 magId "3174443700" @default.
- W3174443700 workType "article" @default.