Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174446586> ?p ?o ?g. }
- W3174446586 abstract "ABSTRACT Numerous motors of the Kinesin family contribute to plus-end directed microtubule transport. However, almost all transport towards the minus-end of microtubules involves Dynein. Understanding the mechanism by which Dynein transports this vast diversity of cargo is the focus of intense research. In select cases, adaptors that link a particular cargo with Dynein have been identified. However, the sheer diversity of cargo suggests that additional adaptors must exist. We used the Drosophila egg chamber as a model to address this issue. Within egg chambers, Egalitarian is required for linking mRNA with Dynein. However, in the absence of Egalitarian, Dynein transport into the oocyte is severely compromised. This suggests that additional cargoes might be liked to Dynein in an Egalitarian-dependent manner. We therefore used proximity biotin ligation to define the interactome of Egalitarian. This approach yielded several novel interacting partners, including P body components and proteins that associate with Dynein in mammalian cells. We also devised and validated a nanobody based proximity biotinylation strategy which can be used to define the interactome of any GFP-tagged protein." @default.
- W3174446586 created "2021-07-05" @default.
- W3174446586 creator A5029016802 @default.
- W3174446586 creator A5046077142 @default.
- W3174446586 creator A5054882422 @default.
- W3174446586 creator A5070952967 @default.
- W3174446586 date "2021-07-02" @default.
- W3174446586 modified "2023-10-14" @default.
- W3174446586 title "In vivo proximity biotin ligation identifies the interactome of Egalitarian, a Dynein cargo adaptor" @default.
- W3174446586 cites W1571632059 @default.
- W3174446586 cites W1966164717 @default.
- W3174446586 cites W1977088071 @default.
- W3174446586 cites W1978135281 @default.
- W3174446586 cites W1978205254 @default.
- W3174446586 cites W1978534363 @default.
- W3174446586 cites W1981648940 @default.
- W3174446586 cites W1987008930 @default.
- W3174446586 cites W1994652034 @default.
- W3174446586 cites W2003798205 @default.
- W3174446586 cites W2009135466 @default.
- W3174446586 cites W2012418668 @default.
- W3174446586 cites W2024829097 @default.
- W3174446586 cites W2027548893 @default.
- W3174446586 cites W2035671523 @default.
- W3174446586 cites W2045095006 @default.
- W3174446586 cites W2052309340 @default.
- W3174446586 cites W2055654853 @default.
- W3174446586 cites W2061053894 @default.
- W3174446586 cites W2061196122 @default.
- W3174446586 cites W2078021348 @default.
- W3174446586 cites W2081049732 @default.
- W3174446586 cites W2088339136 @default.
- W3174446586 cites W2103046819 @default.
- W3174446586 cites W2105436366 @default.
- W3174446586 cites W2108598526 @default.
- W3174446586 cites W2110551795 @default.
- W3174446586 cites W2111621909 @default.
- W3174446586 cites W2124073775 @default.
- W3174446586 cites W2131247762 @default.
- W3174446586 cites W2139192787 @default.
- W3174446586 cites W2149491013 @default.
- W3174446586 cites W2153700596 @default.
- W3174446586 cites W2153974400 @default.
- W3174446586 cites W2154969261 @default.
- W3174446586 cites W2161789834 @default.
- W3174446586 cites W2171061283 @default.
- W3174446586 cites W2203265148 @default.
- W3174446586 cites W2277761135 @default.
- W3174446586 cites W2281379996 @default.
- W3174446586 cites W2292093187 @default.
- W3174446586 cites W2304846645 @default.
- W3174446586 cites W2311366107 @default.
- W3174446586 cites W2396397415 @default.
- W3174446586 cites W2418182841 @default.
- W3174446586 cites W2509514499 @default.
- W3174446586 cites W2548859467 @default.
- W3174446586 cites W2563754444 @default.
- W3174446586 cites W2618279167 @default.
- W3174446586 cites W2744781707 @default.
- W3174446586 cites W2757671806 @default.
- W3174446586 cites W2794045441 @default.
- W3174446586 cites W2800287140 @default.
- W3174446586 cites W2809435919 @default.
- W3174446586 cites W2888618670 @default.
- W3174446586 cites W2891849873 @default.
- W3174446586 cites W2912445897 @default.
- W3174446586 cites W2913735398 @default.
- W3174446586 cites W2949201915 @default.
- W3174446586 cites W2952688584 @default.
- W3174446586 cites W2953034136 @default.
- W3174446586 cites W2965923968 @default.
- W3174446586 cites W2973356406 @default.
- W3174446586 cites W2980567099 @default.
- W3174446586 cites W2986492809 @default.
- W3174446586 cites W3000734662 @default.
- W3174446586 cites W3011958616 @default.
- W3174446586 cites W3019892886 @default.
- W3174446586 cites W3032061648 @default.
- W3174446586 cites W3096587714 @default.
- W3174446586 cites W3131453815 @default.
- W3174446586 cites W3159146513 @default.
- W3174446586 cites W3170359599 @default.
- W3174446586 doi "https://doi.org/10.1101/2021.07.01.450794" @default.
- W3174446586 hasPublicationYear "2021" @default.
- W3174446586 type Work @default.
- W3174446586 sameAs 3174446586 @default.
- W3174446586 citedByCount "1" @default.
- W3174446586 countsByYear W31744465862022 @default.
- W3174446586 crossrefType "posted-content" @default.
- W3174446586 hasAuthorship W3174446586A5029016802 @default.
- W3174446586 hasAuthorship W3174446586A5046077142 @default.
- W3174446586 hasAuthorship W3174446586A5054882422 @default.
- W3174446586 hasAuthorship W3174446586A5070952967 @default.
- W3174446586 hasBestOaLocation W31744465861 @default.
- W3174446586 hasConcept C104317684 @default.
- W3174446586 hasConcept C106987784 @default.
- W3174446586 hasConcept C160408235 @default.
- W3174446586 hasConcept C20418707 @default.
- W3174446586 hasConcept C204628709 @default.
- W3174446586 hasConcept C54355233 @default.