FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174450005> ?p ?o ?g. }

• W3174450005 abstract "Background: Thoracic radiotherapy is complicated by acute radiation-induced adverse events such as radiation pneumonitis (RP) and radiation esophagitis (RE). Based on preclinical work and a randomized pilot trial from our laboratory, this single-arm phase II trial investigated administering flaxseed as a radioprotector in patients receiving definitive chemoradiation for nonsmall cell lung cancer (NSCLC). Methods: Between June 2015 and February 2018, 33 patients with locally advanced or metastatic NSCLC with planned definitive chemoradiation were enrolled. Finely-ground Linum usitatissimum L. (Linaceae; flaxseed or linseed) in 40-g packets were provided for daily consumption in any patient-desired formulation 1 week before radiotherapy and throughout radiotherapy as tolerated. The primary outcomes were overall adverse events, with particular focus on Grade ≥3 RP, and flaxseed tolerability. Adverse events were graded according to CTCAE v4.0. Results: Of the 33 patients enrolled, 5 patients (15%) did not receive chemoradiation, 4 (12%) withdrew promptly after enrollment, 4 (12%) did not return a flaxseed consumption log, and 1 patient had irritable bowel syndrome (3%). The remaining 19 patients (57%) had chemoradiation and flaxseed ingestion with a mean completion and standard deviation of the intended flaxseed course of 62% ± 8.3%. Nine (50%) of these 19 patients reported difficulties with flaxseed consumption, citing nausea, constipation, odynophagia, or poor taste or texture. One patient (5%), with unverifiable flaxseed consumption, developed Grade 3 RP. There were no cases of Grade 2 RP. Six patients (32%) developed Grade 2 RE, but no patients developed Grade ≥3 RE. Median overall and progression-free survival were 31 and 12 months, respectively. Conclusions: Despite the low incidence of acute radiation-induced complications reported, significant treatment-related gastrointestinal toxicities and subsequently low flaxseed tolerability inhibit accurate determination of flaxseed effect in patients receiving concurrent thoracic chemoradiation. Thus, further investigations should focus on optimizing flaxseed formulation for improved tolerability and evaluation. ClinicalTrials.gov ID: NCT02475330." @default.
• W3174450005 created "2021-07-05" @default.
• W3174450005 creator A5008771585 @default.
• W3174450005 creator A5017021744 @default.
• W3174450005 creator A5035062387 @default.
• W3174450005 creator A5035208282 @default.
• W3174450005 creator A5065576440 @default.
• W3174450005 creator A5067536094 @default.
• W3174450005 creator A5070392597 @default.
• W3174450005 creator A5073343147 @default.
• W3174450005 creator A5076092861 @default.
• W3174450005 creator A5082385497 @default.
• W3174450005 creator A5082801249 @default.
• W3174450005 date "2021-06-23" @default.
• W3174450005 modified "2023-09-29" @default.
• W3174450005 title "Phase II Trial of Flaxseed to Prevent Acute Complications After Chemoradiation for Lung Cancer" @default.
• W3174450005 cites W1968899146 @default.
• W3174450005 cites W1971556961 @default.
• W3174450005 cites W1971938662 @default.
• W3174450005 cites W1979600141 @default.
• W3174450005 cites W1985873722 @default.
• W3174450005 cites W1988240230 @default.
• W3174450005 cites W2006265006 @default.
• W3174450005 cites W2011573190 @default.
• W3174450005 cites W2017164285 @default.
• W3174450005 cites W2018165119 @default.
• W3174450005 cites W2021912098 @default.
• W3174450005 cites W2040286149 @default.
• W3174450005 cites W2071289608 @default.
• W3174450005 cites W2075776770 @default.
• W3174450005 cites W2103099107 @default.
• W3174450005 cites W2126614953 @default.
• W3174450005 cites W2136887681 @default.
• W3174450005 cites W2137425540 @default.
• W3174450005 cites W2145213030 @default.
• W3174450005 cites W2155918577 @default.
• W3174450005 cites W2163402696 @default.
• W3174450005 cites W2166988903 @default.
• W3174450005 cites W2167298849 @default.
• W3174450005 cites W2292886889 @default.
• W3174450005 cites W2327770779 @default.
• W3174450005 cites W2410583348 @default.
• W3174450005 cites W2531324265 @default.
• W3174450005 cites W2751756130 @default.
• W3174450005 cites W2753065806 @default.
• W3174450005 cites W2772460351 @default.
• W3174450005 cites W2941546502 @default.
• W3174450005 cites W2969658762 @default.
• W3174450005 cites W3001472142 @default.
• W3174450005 doi "https://doi.org/10.1089/acm.2020.0542" @default.
• W3174450005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34161146" @default.
• W3174450005 hasPublicationYear "2021" @default.
• W3174450005 type Work @default.
• W3174450005 sameAs 3174450005 @default.
• W3174450005 citedByCount "1" @default.
• W3174450005 countsByYear W31744500052023 @default.
• W3174450005 crossrefType "journal-article" @default.
• W3174450005 hasAuthorship W3174450005A5008771585 @default.
• W3174450005 hasAuthorship W3174450005A5017021744 @default.
• W3174450005 hasAuthorship W3174450005A5035062387 @default.
• W3174450005 hasAuthorship W3174450005A5035208282 @default.
• W3174450005 hasAuthorship W3174450005A5065576440 @default.
• W3174450005 hasAuthorship W3174450005A5067536094 @default.
• W3174450005 hasAuthorship W3174450005A5070392597 @default.
• W3174450005 hasAuthorship W3174450005A5073343147 @default.
• W3174450005 hasAuthorship W3174450005A5076092861 @default.
• W3174450005 hasAuthorship W3174450005A5082385497 @default.
• W3174450005 hasAuthorship W3174450005A5082801249 @default.
• W3174450005 hasConcept C126322002 @default.
• W3174450005 hasConcept C141071460 @default.
• W3174450005 hasConcept C197934379 @default.
• W3174450005 hasConcept C2776256026 @default.
• W3174450005 hasConcept C2776980227 @default.
• W3174450005 hasConcept C2777819096 @default.
• W3174450005 hasConcept C2778375690 @default.
• W3174450005 hasConcept C2779134260 @default.
• W3174450005 hasConcept C2779920096 @default.
• W3174450005 hasConcept C2780580376 @default.
• W3174450005 hasConcept C43270747 @default.
• W3174450005 hasConcept C509974204 @default.
• W3174450005 hasConcept C71924100 @default.
• W3174450005 hasConceptScore W3174450005C126322002 @default.
• W3174450005 hasConceptScore W3174450005C141071460 @default.
• W3174450005 hasConceptScore W3174450005C197934379 @default.
• W3174450005 hasConceptScore W3174450005C2776256026 @default.
• W3174450005 hasConceptScore W3174450005C2776980227 @default.
• W3174450005 hasConceptScore W3174450005C2777819096 @default.
• W3174450005 hasConceptScore W3174450005C2778375690 @default.
• W3174450005 hasConceptScore W3174450005C2779134260 @default.
• W3174450005 hasConceptScore W3174450005C2779920096 @default.
• W3174450005 hasConceptScore W3174450005C2780580376 @default.
• W3174450005 hasConceptScore W3174450005C43270747 @default.
• W3174450005 hasConceptScore W3174450005C509974204 @default.
• W3174450005 hasConceptScore W3174450005C71924100 @default.
• W3174450005 hasLocation W31744500051 @default.
• W3174450005 hasLocation W31744500052 @default.
• W3174450005 hasOpenAccess W3174450005 @default.
• W3174450005 hasPrimaryLocation W31744500051 @default.
• W3174450005 hasRelatedWork W1973342136 @default.
• W3174450005 hasRelatedWork W2002502340 @default.

• next