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- W31744913 abstract "Publisher Summary This chapter explains the role of parathyroid hormone (PTH) in bone loss after organ transplantation. PTH has been implicated because it is believed that the immunosuppressive drugs used after organ transplantation, specifically glucocorticoids and calcineurin inhibitors, increase the secretion of PTH. If this were to occur with organ transplantation, PTH could be important in the development of post-transplant osteoporosis. To understand the role of PTH in transplantation osteoporosis, a distinction has to be made between the two phases of post-transplantation bone loss. This is based on the presence or absence of high-dose glucocorticoids. During the initial phase of transplantation, when glucocorticoid doses generally are high enough to profoundly suppress bone formation, PTH does not appear to play an important role. During the second post-transplant phase, after glucocorticoids have typically been reduced, PTH could become an important contributor to bone loss. In the later period after transplantation, there is evidence to suggest that elevated PTH levels, likely caused by calcineurin inhibitor-associated renal insufficiency, may play a contributory role in the ongoing bone loss, although clear histomorphometric evidence is lacking, and other evidence has provided conflicting results." @default.
- W31744913 created "2016-06-24" @default.
- W31744913 creator A5013126573 @default.
- W31744913 creator A5089834841 @default.
- W31744913 date "2005-01-01" @default.
- W31744913 modified "2023-09-26" @default.
- W31744913 title "The Role of Parathyroid Hormone in the Evolution of Bone Loss after Organ Transplantation" @default.
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