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• W3174511526 abstract "As an intermediate substance of the tricarboxylic acid cycle and a precursor substance of glutamic acid synthesis, the effect of alpha-ketoglutarate on growth and protein synthesis has been extensively studied. However, its prevention and treatment of pathogenic bacteria and its mechanism have not yet been noticed. To evaluate the effects of alpha-ketoglutarate on intestinal antioxidant capacity and immune response of Songpu mirror carp, a total of 360 fish with an average initial weight of 6.54 ± 0.08 g were fed diets containing alpha-ketoglutarate with 1% for 8 weeks. At the end of the feeding trial, the fish were challenged with Aeromonas hydrophila for 2 weeks. The results indicated that alpha-ketoglutarate supplementation significantly increased the survival rate of carp after infection with Aeromonas hydrophila (P < 0.05), and the contents of immune digestion enzymes including lysozyme, alkaline phosphatase and the concentration of complement C4 were markedly enhanced after alpha-ketoglutarate supplementation (P < 0.05). Also, appropriate alpha-ketoglutarate increased the activities of total antioxidant capacity and catalase and prevented the up-regulation in the mRNA expression levels of pro-inflammatory cytokines including tumor necrosis factor-α, interleukin-1β, interleukin-6, and interleukin-8 (P < 0.05). Furthermore, the mRNA expression levels of toll-like receptor 4 (TLR4), and nuclear factor kappa-B (NF-κB) were strikingly increased after infection with Aeromonas hydrophila (P < 0.05), while the TLR4 was strikingly decreased with alpha-ketoglutarate supplementation (P < 0.05). Moreover, the mRNA expression levels of tight junctions including claudin-1, claudin-3, claudin-7, claudin-11 and myosin light chain kinases (MLCK) were upregulated after alpha-ketoglutarate supplementation (P < 0.05). In summary, the appropriate alpha-ketoglutarate supplementation could increase survival rate, strengthen the intestinal enzyme immunosuppressive activities, antioxidant capacities and alleviate the intestinal inflammation, thereby promoting the intestinal immune responses and barrier functions of Songpu mirror carp via activating TLR4/MyD88/NF-κB and MLCK signaling pathways after infection with Aeromonas hydrophila." @default.
• W3174511526 created "2021-07-05" @default.
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• W3174511526 date "2021-06-18" @default.
• W3174511526 modified "2023-10-18" @default.
• W3174511526 title "Evaluation of Alpha-Ketoglutarate Supplementation on the Improvement of Intestinal Antioxidant Capacity and Immune Response in Songpu Mirror Carp (Cyprinus carpio) After Infection With Aeromonas hydrophila" @default.
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• W3174511526 cites W1860693578 @default.
• W3174511526 cites W1902824041 @default.
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• W3174511526 cites W1964163204 @default.
• W3174511526 cites W1975817646 @default.
• W3174511526 cites W1977720886 @default.
• W3174511526 cites W1986183433 @default.
• W3174511526 cites W1989151465 @default.
• W3174511526 cites W1993065952 @default.
• W3174511526 cites W1997990296 @default.
• W3174511526 cites W2001747259 @default.
• W3174511526 cites W2002706411 @default.
• W3174511526 cites W2003151745 @default.
• W3174511526 cites W2004723568 @default.
• W3174511526 cites W2010922341 @default.
• W3174511526 cites W2022907336 @default.
• W3174511526 cites W2032349776 @default.
• W3174511526 cites W2032454111 @default.
• W3174511526 cites W2034017940 @default.
• W3174511526 cites W2036767516 @default.
• W3174511526 cites W2040898591 @default.
• W3174511526 cites W2044261235 @default.
• W3174511526 cites W2054679924 @default.
• W3174511526 cites W2055222262 @default.
• W3174511526 cites W2058626068 @default.
• W3174511526 cites W2059692941 @default.
• W3174511526 cites W2060948257 @default.
• W3174511526 cites W2070620754 @default.
• W3174511526 cites W2079149627 @default.
• W3174511526 cites W2101929583 @default.
• W3174511526 cites W2107249970 @default.
• W3174511526 cites W2111322904 @default.
• W3174511526 cites W2112503704 @default.
• W3174511526 cites W2113315367 @default.
• W3174511526 cites W2115145729 @default.
• W3174511526 cites W2121979986 @default.
• W3174511526 cites W2123230988 @default.
• W3174511526 cites W2127964730 @default.
• W3174511526 cites W2150912898 @default.
• W3174511526 cites W2302022292 @default.
• W3174511526 cites W2313178014 @default.
• W3174511526 cites W2319604123 @default.
• W3174511526 cites W2340744966 @default.
• W3174511526 cites W2345485999 @default.
• W3174511526 cites W2463493657 @default.
• W3174511526 cites W2469239257 @default.
• W3174511526 cites W2504495822 @default.
• W3174511526 cites W2512378822 @default.
• W3174511526 cites W2554344587 @default.
• W3174511526 cites W2592855024 @default.
• W3174511526 cites W2605282862 @default.
• W3174511526 cites W2607890315 @default.
• W3174511526 cites W2624567362 @default.
• W3174511526 cites W2746897940 @default.
• W3174511526 cites W2748728899 @default.
• W3174511526 cites W2750087623 @default.
• W3174511526 cites W2772207615 @default.
• W3174511526 cites W2781816595 @default.
• W3174511526 cites W2783143882 @default.
• W3174511526 cites W2789883459 @default.
• W3174511526 cites W2893782628 @default.
• W3174511526 cites W2939288717 @default.
• W3174511526 cites W2951992399 @default.
• W3174511526 cites W2969892182 @default.
• W3174511526 cites W2980212815 @default.
• W3174511526 cites W2982635392 @default.
• W3174511526 cites W3001513967 @default.
• W3174511526 cites W3013352992 @default.
• W3174511526 cites W3036926292 @default.
• W3174511526 cites W3047439314 @default.
• W3174511526 cites W3082803056 @default.
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• W3174511526 doi "https://doi.org/10.3389/fimmu.2021.690234" @default.
• W3174511526 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8250152" @default.
• W3174511526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34220849" @default.
• W3174511526 hasPublicationYear "2021" @default.
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