FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174580909> ?p ?o ?g. }

• W3174580909 endingPage "1208" @default.
• W3174580909 startingPage "1203" @default.
• W3174580909 abstract "Abstract BACKGROUND Hypertension is common in hemodialysis (HD) patients. Increased blood pressure (BP) variability, particularly higher and lower extremes, is associated with adverse outcomes. We explored the association of endothelin-1 (ET-1), a potent vasoconstrictor, with different BP parameters (pre-HD, intra-HD, and post-HD) during HD in a contemporary patient cohort. METHODS This study uses the DaVita Biorepository, a longitudinal prospective cohort study with quarterly collection of clinical data and biospecimens. Unadjusted and adjusted linear mixed effects regression models were fit to determine association of pre-HD ET-1 (log-transformed and quartiles) with HD-related systolic BP (SBP) parameters (pre-HD, nadir intra-HD, and post-HD). As ET-1 was measured at baseline, analyses were restricted to 1 year of follow-up. RESULTS Among 769 participants, mean age was 52 years, 42% were females, and 41% were Black. Mean pre-HD SBP was 152 (±28) mm Hg and mean ET-1 concentration was 2.3 (±1.2) ng/ml. In fully adjusted models, each unit increase in SD of log-transformed ET-1 was associated with a 2.7 (95% confidence interval [CI] 1.5, 4.0) mm Hg higher pre-SBP; 1.6 (95% CI 0.9, 2.3) mm Hg higher nadir SBP; and 2.0 (95% CI 1.1, 2.9) mm Hg higher post-SBP. Each SD increase in log-transformed ET-1 was associated with 21% higher odds of experiencing intradialytic hypertension (odds ratio 1.21; 95% CI 1.10–1.34). CONCLUSIONS Higher baseline ET-1 levels are independently associated with higher SBP and higher odds of intradialytic hypertension. These results highlight a potential role for ET-1 in BP control in HD patients and raise the possibility of ET-1 antagonism as a therapeutic target." @default.
• W3174580909 created "2021-07-05" @default.
• W3174580909 creator A5011994381 @default.
• W3174580909 creator A5029578541 @default.
• W3174580909 creator A5051178808 @default.
• W3174580909 creator A5064518665 @default.
• W3174580909 creator A5073070877 @default.
• W3174580909 creator A5081409622 @default.
• W3174580909 date "2021-06-30" @default.
• W3174580909 modified "2023-10-16" @default.
• W3174580909 title "Endothelin-1 and Parameters of Systolic Blood Pressure in Hemodialysis" @default.
• W3174580909 cites W1914057575 @default.
• W3174580909 cites W1972565751 @default.
• W3174580909 cites W1981831829 @default.
• W3174580909 cites W1984659199 @default.
• W3174580909 cites W1986638696 @default.
• W3174580909 cites W1991210746 @default.
• W3174580909 cites W2012577488 @default.
• W3174580909 cites W2018254999 @default.
• W3174580909 cites W2058271386 @default.
• W3174580909 cites W2062339791 @default.
• W3174580909 cites W2068442384 @default.
• W3174580909 cites W2098636543 @default.
• W3174580909 cites W2100646850 @default.
• W3174580909 cites W2100732774 @default.
• W3174580909 cites W2107550750 @default.
• W3174580909 cites W2108421819 @default.
• W3174580909 cites W2111654578 @default.
• W3174580909 cites W2125122609 @default.
• W3174580909 cites W2127195061 @default.
• W3174580909 cites W2130991130 @default.
• W3174580909 cites W2150333966 @default.
• W3174580909 cites W2151570134 @default.
• W3174580909 cites W2157285857 @default.
• W3174580909 cites W2161923453 @default.
• W3174580909 cites W2169032372 @default.
• W3174580909 cites W2179775398 @default.
• W3174580909 cites W2409073940 @default.
• W3174580909 cites W2531308596 @default.
• W3174580909 cites W2535934343 @default.
• W3174580909 cites W2589469610 @default.
• W3174580909 cites W2736116220 @default.
• W3174580909 cites W2794570213 @default.
• W3174580909 cites W2895682445 @default.
• W3174580909 cites W2937955146 @default.
• W3174580909 cites W3009134564 @default.
• W3174580909 cites W3023199095 @default.
• W3174580909 doi "https://doi.org/10.1093/ajh/hpab104" @default.
• W3174580909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34192305" @default.
• W3174580909 hasPublicationYear "2021" @default.
• W3174580909 type Work @default.
• W3174580909 sameAs 3174580909 @default.
• W3174580909 citedByCount "2" @default.
• W3174580909 countsByYear W31745809092022 @default.
• W3174580909 countsByYear W31745809092023 @default.
• W3174580909 crossrefType "journal-article" @default.
• W3174580909 hasAuthorship W3174580909A5011994381 @default.
• W3174580909 hasAuthorship W3174580909A5029578541 @default.
• W3174580909 hasAuthorship W3174580909A5051178808 @default.
• W3174580909 hasAuthorship W3174580909A5064518665 @default.
• W3174580909 hasAuthorship W3174580909A5073070877 @default.
• W3174580909 hasAuthorship W3174580909A5081409622 @default.
• W3174580909 hasBestOaLocation W31745809091 @default.
• W3174580909 hasConcept C126322002 @default.
• W3174580909 hasConcept C156957248 @default.
• W3174580909 hasConcept C164705383 @default.
• W3174580909 hasConcept C188816634 @default.
• W3174580909 hasConcept C2778063415 @default.
• W3174580909 hasConcept C44249647 @default.
• W3174580909 hasConcept C57900726 @default.
• W3174580909 hasConcept C68443243 @default.
• W3174580909 hasConcept C71924100 @default.
• W3174580909 hasConcept C84393581 @default.
• W3174580909 hasConceptScore W3174580909C126322002 @default.
• W3174580909 hasConceptScore W3174580909C156957248 @default.
• W3174580909 hasConceptScore W3174580909C164705383 @default.
• W3174580909 hasConceptScore W3174580909C188816634 @default.
• W3174580909 hasConceptScore W3174580909C2778063415 @default.
• W3174580909 hasConceptScore W3174580909C44249647 @default.
• W3174580909 hasConceptScore W3174580909C57900726 @default.
• W3174580909 hasConceptScore W3174580909C68443243 @default.
• W3174580909 hasConceptScore W3174580909C71924100 @default.
• W3174580909 hasConceptScore W3174580909C84393581 @default.
• W3174580909 hasFunder F4320332161 @default.
• W3174580909 hasFunder F4320337357 @default.
• W3174580909 hasIssue "11" @default.
• W3174580909 hasLocation W31745809091 @default.
• W3174580909 hasLocation W31745809092 @default.
• W3174580909 hasLocation W31745809093 @default.
• W3174580909 hasOpenAccess W3174580909 @default.
• W3174580909 hasPrimaryLocation W31745809091 @default.
• W3174580909 hasRelatedWork W2055211800 @default.
• W3174580909 hasRelatedWork W2116633522 @default.
• W3174580909 hasRelatedWork W2417485714 @default.
• W3174580909 hasRelatedWork W2520656145 @default.
• W3174580909 hasRelatedWork W3023816155 @default.
• W3174580909 hasRelatedWork W3202777321 @default.
• W3174580909 hasRelatedWork W4309740539 @default.

• next