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- W3174618485 abstract "Space flight-induced orthostatic intolerance (OI) is more prevalent in female (F) than male (M) astronauts. The mechanisms explaining the higher incidence of OI in F are unclear. We tested the hypothesis that venous compliance would be higher in F more than M following 6° head-down bed rest (BR) and would be associated with constrictor dysfunction. Using 2-D ultrasound, dorsal hand (DHV) and dorsal foot (DFV) vein compliance were determined in 24 subjects (10 F, 14 M; 35±1 yr) by measuring mean diameter response to increasing congestion pressure (0, 20, 30, and 40 mmHg) before and after 60 days of BR. Constrictor function was assessed by intravenous infusions of Ketorolac (KE; 1.5 μg/min), Phenylephrine (PE; 3160 ng/min), and L-NMMA (50 μg/min). The effect of BR between F vs. M and hand vs. foot, was determined using mixed-effects linear regression. DFV but not DHV compliance changed in response to BR (p=0.012). Mean DFV increased significantly (0.903 mm to 1.191 mm) in F but decreased in M (1.353 mm to 1.154 mm). DFV constrictor response was not different between sexes in response to BR (KE; p=0.647, PE; p=0.717, and L-NMMA; p=0.825). These data suggest that the higher incidence of OI in F astronauts may be related to increased lower limb venous compliance, contributing to blood pooling upon standing. Notably, the differential change to DFV compliance between sexes was not associated with impaired constrictor function." @default.
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- W3174618485 date "2012-04-01" @default.
- W3174618485 modified "2023-10-16" @default.
- W3174618485 title "The change in lower limb venous compliance is different between women and men following 60 days of head‐down bedrest but is not associated with venoconstrictor dysfunction" @default.
- W3174618485 doi "https://doi.org/10.1096/fasebj.26.1_supplement.1085.5" @default.
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