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• W3174641319 abstract "The present paper provides a systematic review aimed at identifying studies on pharmacological interactions in patients undergoing hematopoietic stem cell transplantation. Secondary objectives include a characterization of the prevalence of such interactions and an investigation of their specific characteristics.A search was performed of the terms drug-drug interaction, drug interaction, stem cell transplant, transplantation conditioning, and conditioning regimen in the PubMed database, and of the terms drug interaction, stem cell transplantation, and transplantation conditioning in the Embase database. Only results directly related to the objective of the review were selected. Studies in humans published between January 2000 and November 2020, written in English or Spanish, were prioritized.The review identified two groups of studies: epidemiological studies and studies analyzing interactions between specific drugs. The 10 epidemiological studies selected, which showed a prevalence of interactions between 60 and 100%, mainly used the Micromedex® database, focused on pharmacokinetic interactions involving azole antifungals.Results were highly heterogeneous. Of the 52 drug interaction studies reviewed, the majority were pharmacokinetic and focused primarily on the interactions of azole antifungals with calcineurin inhibitors. Some studies described the possible relationship between the interactions and specific adverse reactions or deaths from adverse events.The prevalence of drug-drug interactions in patients undergoing hematopoietic stem cell transplantation is high, with heterogeneous results both in terms of prevalence and of the profile of the interactions resulting from the use of disparate study designs and databases. The most common factor associated with drug-drug interactions was the number of drugs administered. Studies evaluating drug-drug interactions are mostly pharmacokinetic and focus mainly on azole antifungals and calcineurin inhibitors. It would be important to unify the criteria followed in epidemiological studies to obtain results that may help establish risk reduction strategies and conduct a more in-depth investigation into the pharmacodynamic mechanisms involved and into the interactions between other drugs frequently used in patients undergoing transplantation, including those recently introduced in our therapeutic arsenal.Objetivo: El objetivo principal de este trabajo es identificar, mediante revisión bibliográfica sistemática, los estudios sobre interacciones farmacológicas en pacientes sometidos a trasplante de progenitores hematopoyéticos. Los objetivos secundarios son describir la prevalencia de dichas interacciones y extraer información de interacciones fármaco-fármaco concretas.Método: Búsquedas en PubMed con los términos “drug-drug interaction”, “drug interaction”, “stem cell transplant”, “transplantation conditioning” y “conditioning regimen” y en Embase “drug interaction”, “stem cell transplantation” y “transplantation conditioning”, seleccionando aquellos resultados relacionados directamente con el objetivo de la revisión. Se priorizaron estudios en humanos, en idiomas inglés y español, entre enero de 2000 y noviembre de 2020.Resultados: La revisión identificó dos grupos de estudios epidemiológicos y de análisis de interacciones entre fármacos concretos). Los 10 estudios epidemiológicos mostraron una prevalencia de interacciones entre el 60% y el 100%, la base de datos más utilizada fue Micromedex®, el mecanismo farmacocinético y los fármacos más implicados fueron los antifúngicos azólicos, con resultados muy heterogéneos. Los 52 estudios de interacciones entre fármacos fueron casi todos farmacocinéticos y se centraron fundamentalmente en las interacciones de antifúngicos azólicos e inhibidores de la calcineurina. Algunos estudios describieron la posible relación entre interacciones y reacciones adversas concretas o muertes por efectos adversos.Conclusiones: La prevalencia de interacciones en pacientes sometidos a trasplante de progenitores hematopoyéticos es elevada, siendo los esultados heterogéneos, tanto en prevalencia como en el perfil de las interacciones. En ello repercuten las diferencias en los diseños de los estudios y en las bases de datos utilizadas. Entre los factores relacionados con el riesgo de que se produzcan interacciones farmacológicas destaca el elevado número de fármacos administrados. Los estudios que evalúan las interacciones fármaco-fármaco son casi todos farmacocinéticos y se centran mayoritariamente en antifúngicos azólicos e inhibidores de la calcineurina. Sería importante unificar los criterios de los estudios epidemiológicos para obtener resultados que ayuden a establecer estrategias de reducción de riesgo, investigar en mayor profundidad las interacciones de mecanismo farmacodinámico, las interacciones entre otros fármacos de uso frecuente en el trasplante y en aquellos de introducción reciente en el arsenal terapéutico." @default.
• W3174641319 created "2021-07-05" @default.
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• W3174641319 date "2021-06-03" @default.
• W3174641319 modified "2023-09-26" @default.
• W3174641319 title "Drug-drug interactions in patients undergoing hematopoietic stem cell transplantation: systematic review." @default.
• W3174641319 doi "https://doi.org/10.7399/fh.11627" @default.
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