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- W3174647003 abstract "We have previously shown that ischemic-reperfusion (I/R) related blood-brain barrier (BBB) dysfunction represents an important component of ischemic brain damage in the fetus. Pro-inflammatory cytokines have been implicated in the pathogenesis of I/R related brain injury. We tested the hypothesis that ischemia accentuates the transfer of systemic IL-1β across the BBB in the ovine fetus. Chronically instrumented fetuses at 85% of gestation were studied after 30 min of bilateral carotid artery occlusion and 4 h of reperfusion, and compared with a non-ischemic sham-operated control group. Recombinant ovine IL-1β protein was expressed from an IL-1β pGEX-2T vector in E. Coli BL-21 cells. We radiolabeled the ovine IL-1β protein with 125I. BBB function was quantified in 10 brain regions using the blood-to-brain transfer constant (Ki) with intravenously injected 125I-radiolabeled ovine IL-1β. Systemic IL-1β crossed the intact fetal BBB. Ki measured with IL-1β was higher (ANOVA, F=5.1, P<0.05) across brain regions of the fetuses exposed to ischemia than of the non-ischemic fetuses. Ischemia with reperfusion for 4 h increased the transfer of IL-1β across the blood-brain barrier in the ovine fetus. Consequently, impaired blood-brain barrier function after hypoxia-ischemia facilitates the entry of systemic cytokines into the brain parenchyma, where they could accentuate brain damage. NIH-HD-057100" @default.
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- W3174647003 date "2012-04-01" @default.
- W3174647003 modified "2023-09-23" @default.
- W3174647003 title "Ischemia Accentuates the Transfer of Interleukin‐1β Across the Blood‐Brain Barrier in the Ovine Fetus" @default.
- W3174647003 doi "https://doi.org/10.1096/fasebj.26.1_supplement.707.1" @default.
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