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- W3174650224 abstract "This study was done to investigate the effect of chronic intermittent hypoxia (CIH) during gestation on the development of offspring. Female Sprague-Dawley rats were mated, housed individually, and kept on a standard rat chow diet during the study. Pregnant females (n=8) were exposed daily to CIH (6.5% O2 nadir; 18 cycles/h; 8 h/day) from gestational day-1 to day-20. Control (n=6) mothers were exposed similarly to room air. Postnatal day-1 offspring from CIH mothers showed significantly lower body weights, and lower liver-to-body weight ratios. By 12-wk of age, body weights of growth restricted offspring were significantly greater, as were the liver-to-body weight ratios. These offspring also had greater body fat deposition and elevated circulating cholesterol levels at both 6-wk and 12-wk of age. Western blot and qPCR analysis showed that CIH offspring had decreased protein and gene expression of markers vital for cholesterol regulation in the liver, including Liver X Receptor (LXR), ABCA1 (cholesterol efflux) and the LDL receptor (cholesterol catabolism). These data show that alteration of the maternal intrauterine environment by gestational CIH has significant consequences on the long-term development of offspring and increases the disposition of the animals to metabolic diseases in adulthood. Supported by Heart and Stroke Foundation and Canadian Institutes of Health Research" @default.
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- W3174650224 date "2012-04-01" @default.
- W3174650224 modified "2023-09-23" @default.
- W3174650224 title "Gestational chronic intermittent hypoxia causes asymmetric growth restriction and alters cholesterol homeostasis in the liver of sprague‐dawley rats" @default.
- W3174650224 doi "https://doi.org/10.1096/fasebj.26.1_supplement.1101.3" @default.
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