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- W3174654519 endingPage "6584" @default.
- W3174654519 startingPage "6584" @default.
- W3174654519 abstract "Little is known about the impairments and pathological changes in the visual system in mild brain trauma, especially repetitive mild traumatic brain injury (mTBI). The goal of this study was to examine and compare the effects of repeated head impacts on the neurodegeneration, axonal integrity, and glial activity in the optic tract (OT), as well as on neuronal preservation, glial responses, and synaptic organization in the lateral geniculate nucleus (LGN) and superior colliculus (SC), in wild-type mice and transgenic animals with overexpression of human TDP-43 mutant protein (TDP-43G348C) at 6 months after repeated closed head traumas. Animals were also assessed in the Barnes maze (BM) task. Neurodegeneration, axonal injury, and gliosis were detected in the OT of the injured animals of both genotypes. In the traumatized mice, myelination of surviving axons was mostly preserved, and the expression of neurofilament light chain was unaffected. Repetitive mTBI did not induce changes in the LGN and the SC, nor did it affect the performance of the BM task in the traumatized wild-type and TDP-43 transgenic mice. Differences in neuropathological and behavioral assessments between the injured wild-type and TDP-43G348C mice were not revealed. Results of the current study suggest that repetitive mTBI was associated with chronic damage and inflammation in the OT in wild-type and TDP-43G348C mice, which were not accompanied with behavioral problems and were not affected by the TDP-43 genotype, while the LGN and the SC remained preserved in the used experimental conditions." @default.
- W3174654519 created "2021-07-05" @default.
- W3174654519 creator A5020540455 @default.
- W3174654519 creator A5026698227 @default.
- W3174654519 creator A5043695404 @default.
- W3174654519 creator A5060388651 @default.
- W3174654519 creator A5070320595 @default.
- W3174654519 creator A5075316973 @default.
- W3174654519 creator A5082801768 @default.
- W3174654519 date "2021-06-19" @default.
- W3174654519 modified "2023-09-26" @default.
- W3174654519 title "Long-Term Effects of Repetitive Mild Traumatic Injury on the Visual System in Wild-Type and TDP-43 Transgenic Mice" @default.
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- W3174654519 doi "https://doi.org/10.3390/ijms22126584" @default.