FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174668840> ?p ?o ?g. }

• W3174668840 endingPage "1063" @default.
• W3174668840 startingPage "1052" @default.
• W3174668840 abstract "Gossypol has been reported to exhibit antitumor effects against several human cancers. However, the anticancer effects of gossypol on nasopharyngeal carcinoma (NPC) have not been investigated. Against this backdrop, the present study was designed to evaluate the anticancer effects of gossypol against NPC cells and to identify the signaling pathways involved through bioinformatic analysis. Gossypol-inhibited death of NPC cells is concentration-dependent. To explore the underlying mechanism for gossypol's antitumor effect, microarray of gossypol-treated and -untreated NPC cells was performed. A total of 836 differentially expressing genes (DEGs) were identified in gossypol-treated NPC cells, of which 461 genes were upregulated and 375 genes were downregulated. The cellular components, molecular functions, biological processes, and signal pathways, in which the DEGs were involved, were identified by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). The Gene Set Enrichment Analysis (GSEA) predicted upstream transcription factors (TF) ETS2 and E2F1 that regulate DEGs. Weighted Gene Co-expression Network Analysis (WGCNA) was performed to identify a class of modules and genes related to DNA repair and cell cycle. TNFRSF10B, a receptor for death in NPC cells, was knocked down. The results suggested that the ability of NPC cells to resist gossypol killing was enhanced. In addition, to further investigate the possible molecular mechanisms, we constructed a transcriptional regulatory network of TNFRSF10B containing 109 miRNAs and 47 TFs. Taken together, our results demonstrated that gossypol triggered antitumor effects against NPC cells, indicating its applicability for the management of NPC." @default.
• W3174668840 created "2021-07-05" @default.
• W3174668840 creator A5010645590 @default.
• W3174668840 creator A5018822326 @default.
• W3174668840 creator A5019448133 @default.
• W3174668840 creator A5034673563 @default.
• W3174668840 creator A5035740553 @default.
• W3174668840 creator A5041502864 @default.
• W3174668840 creator A5052572849 @default.
• W3174668840 creator A5067352428 @default.
• W3174668840 creator A5075877965 @default.
• W3174668840 creator A5081985857 @default.
• W3174668840 creator A5086070899 @default.
• W3174668840 creator A5090923511 @default.
• W3174668840 date "2021-08-01" @default.
• W3174668840 modified "2023-09-24" @default.
• W3174668840 title "Bioinformatics Analysis of the Signaling Pathways and Genes of Gossypol Induce Death of Nasopharyngeal Carcinoma Cells" @default.
• W3174668840 cites W1514164885 @default.
• W3174668840 cites W1546952499 @default.
• W3174668840 cites W1553060509 @default.
• W3174668840 cites W1807250471 @default.
• W3174668840 cites W1964551602 @default.
• W3174668840 cites W1966327575 @default.
• W3174668840 cites W1969727436 @default.
• W3174668840 cites W1976108799 @default.
• W3174668840 cites W1981424043 @default.
• W3174668840 cites W1982974502 @default.
• W3174668840 cites W2001964408 @default.
• W3174668840 cites W2035618305 @default.
• W3174668840 cites W2052998306 @default.
• W3174668840 cites W2064488040 @default.
• W3174668840 cites W2082177320 @default.
• W3174668840 cites W2082530208 @default.
• W3174668840 cites W2111346575 @default.
• W3174668840 cites W2115591535 @default.
• W3174668840 cites W2116212750 @default.
• W3174668840 cites W2119089141 @default.
• W3174668840 cites W2130410032 @default.
• W3174668840 cites W2131412402 @default.
• W3174668840 cites W2138541620 @default.
• W3174668840 cites W2141224543 @default.
• W3174668840 cites W2144789001 @default.
• W3174668840 cites W2153679407 @default.
• W3174668840 cites W2164539951 @default.
• W3174668840 cites W2346568950 @default.
• W3174668840 cites W2408958865 @default.
• W3174668840 cites W2444660605 @default.
• W3174668840 cites W2555971816 @default.
• W3174668840 cites W2596704275 @default.
• W3174668840 cites W2607625935 @default.
• W3174668840 cites W2625764591 @default.
• W3174668840 cites W2752262703 @default.
• W3174668840 cites W2771019114 @default.
• W3174668840 cites W2811263842 @default.
• W3174668840 cites W2894867652 @default.
• W3174668840 cites W2898273645 @default.
• W3174668840 cites W2899999420 @default.
• W3174668840 cites W2910020921 @default.
• W3174668840 cites W2912897219 @default.
• W3174668840 cites W2937338635 @default.
• W3174668840 cites W2953447885 @default.
• W3174668840 cites W2970869308 @default.
• W3174668840 cites W2999333529 @default.
• W3174668840 cites W3002073397 @default.
• W3174668840 cites W3009867483 @default.
• W3174668840 cites W3016169192 @default.
• W3174668840 cites W3021944451 @default.
• W3174668840 cites W3092182663 @default.
• W3174668840 cites W3133635980 @default.
• W3174668840 cites W4211017340 @default.
• W3174668840 doi "https://doi.org/10.1089/dna.2020.6348" @default.
• W3174668840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34191589" @default.
• W3174668840 hasPublicationYear "2021" @default.
• W3174668840 type Work @default.
• W3174668840 sameAs 3174668840 @default.
• W3174668840 citedByCount "4" @default.
• W3174668840 countsByYear W31746688402021 @default.
• W3174668840 countsByYear W31746688402022 @default.
• W3174668840 countsByYear W31746688402023 @default.
• W3174668840 crossrefType "journal-article" @default.
• W3174668840 hasAuthorship W3174668840A5010645590 @default.
• W3174668840 hasAuthorship W3174668840A5018822326 @default.
• W3174668840 hasAuthorship W3174668840A5019448133 @default.
• W3174668840 hasAuthorship W3174668840A5034673563 @default.
• W3174668840 hasAuthorship W3174668840A5035740553 @default.
• W3174668840 hasAuthorship W3174668840A5041502864 @default.
• W3174668840 hasAuthorship W3174668840A5052572849 @default.
• W3174668840 hasAuthorship W3174668840A5067352428 @default.
• W3174668840 hasAuthorship W3174668840A5075877965 @default.
• W3174668840 hasAuthorship W3174668840A5081985857 @default.
• W3174668840 hasAuthorship W3174668840A5086070899 @default.
• W3174668840 hasAuthorship W3174668840A5090923511 @default.
• W3174668840 hasConcept C104317684 @default.
• W3174668840 hasConcept C126322002 @default.
• W3174668840 hasConcept C150194340 @default.
• W3174668840 hasConcept C152724338 @default.
• W3174668840 hasConcept C162317418 @default.
• W3174668840 hasConcept C18431079 @default.

• next