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- W3174687593 abstract "Diadenosine polyphosphates increase during coronary ischemia. To analyze their role in coronary ischemia-reperfusion, the response to diadenosine tetrataphosphate (Ap4A, 10−7 - 10−5 M) was recorded in isolated perfused rat hearts after precontraction of the coronary vasculature with 11-dideoxy-1a,9a-epoxymethanoprostaglandin F2α (U46619, 10−8 -3×10−8). In control hearts, Ap4A produced concentration-dependent vasodilatation both at the basal coronary resting tone or after precontracting coronary vasculature with U46619, and this vasodilatation was reduced by the antagonist of purinergic P2Y receptors reactive blue 2 (2×10−6 M) and the blocker of ATP-sensitive potassium channels (KATP) glibenclamide (10−5 M). After ischemia-reperfusion, the vasodilatation to Ap4A diminished, and in this case the relaxation to Ap4A was not modified by reactive blue 2 or glibenclamide. The agonist of P2Y purinergic receptors UTP (10−7 - 10−5 M) produced coronary vasodilatation which also was reduced after ischemia-reperfusion. These results suggest that the coronary relaxation to Ap4A is reduced after ischemia-reperfusion, and that this reduction may be due to impaired response of purinergic P2Y receptors and of KATP potassium channels. (Supported by FMMA grant Nº AP57242009 and FIS grant Nº PS09/00394)" @default.
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- W3174687593 date "2011-04-01" @default.
- W3174687593 modified "2023-09-23" @default.
- W3174687593 title "Reduced coronary vasodilatation to diadenosine tetraphosphate after ischemia‐reperfusion in isolated rat heart" @default.
- W3174687593 doi "https://doi.org/10.1096/fasebj.25.1_supplement.1025.1" @default.
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