SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174691615> ?p ?o ?g. }

Showing items 1 to 100 of ±129 with 100 items per page.

W3174691615 endingPage "1371" @default.
W3174691615 startingPage "1353" @default.
W3174691615 abstract "Congenital tufting enteropathy (CTE) is an intractable diarrheal disease of infancy caused by mutations of epithelial cell adhesion molecule (EpCAM). The cellular and molecular basis of CTE pathology has been elusive. We hypothesized that the loss of EpCAM in CTE results in altered lineage differentiation and defects in absorptive enterocytes thereby contributing to CTE pathogenesis.Intestine and colon from mice expressing a CTE-associated mutant form of EpCAM (mutant mice) were evaluated for specific markers by quantitative real-time polymerase chain reaction, Western blotting, and immunostaining. Body weight, blood glucose, and intestinal enzyme activity were also investigated. Enteroids derived from mutant mice were used to assess whether the decreased census of major secretory cells could be rescued.Mutant mice exhibited alterations in brush-border ultrastructure, function, disaccharidase activity, and glucose absorption, potentially contributing to nutrient malabsorption and impaired weight gain. Altered cell differentiation in mutant mice led to decreased enteroendocrine cells and increased numbers of nonsecretory cells, though the hypertrophied absorptive enterocytes lacked key features, causing brush border malfunction. Further, treatment with the Notch signaling inhibitor, DAPT, increased the numbers of major secretory cell types in mutant enteroids (graphical abstract 1).Alterations in intestinal epithelial cell differentiation in mutant mice favor an increase in absorptive cells at the expense of major secretory cells. Although the proportion of absorptive enterocytes is increased, they lack key functional properties. We conclude that these effects underlie pathogenic features of CTE such as malabsorption and diarrhea, and ultimately the failure to thrive seen in patients." @default.
W3174691615 created "2021-07-05" @default.
W3174691615 creator A5002907035 @default.
W3174691615 creator A5010798854 @default.
W3174691615 creator A5062223587 @default.
W3174691615 creator A5064557742 @default.
W3174691615 creator A5073690542 @default.
W3174691615 creator A5073788764 @default.
W3174691615 date "2021-01-01" @default.
W3174691615 modified "2023-10-14" @default.
W3174691615 title "Aberrant Epithelial Differentiation Contributes to Pathogenesis in a Murine Model of Congenital Tufting Enteropathy" @default.
W3174691615 cites W1981234066 @default.
W3174691615 cites W1981773624 @default.
W3174691615 cites W1981920487 @default.
W3174691615 cites W1983344050 @default.
W3174691615 cites W1991346408 @default.
W3174691615 cites W1996543394 @default.
W3174691615 cites W1998453182 @default.
W3174691615 cites W1999172670 @default.
W3174691615 cites W2002907969 @default.
W3174691615 cites W2017218715 @default.
W3174691615 cites W2019284666 @default.
W3174691615 cites W2023304735 @default.
W3174691615 cites W2024121049 @default.
W3174691615 cites W2029446336 @default.
W3174691615 cites W2033167307 @default.
W3174691615 cites W2049792810 @default.
W3174691615 cites W2052891178 @default.
W3174691615 cites W2058669904 @default.
W3174691615 cites W2060013640 @default.
W3174691615 cites W2065878510 @default.
W3174691615 cites W2081471404 @default.
W3174691615 cites W2112723692 @default.
W3174691615 cites W2130544574 @default.
W3174691615 cites W2151040238 @default.
W3174691615 cites W2158553326 @default.
W3174691615 cites W2163374484 @default.
W3174691615 cites W2163899199 @default.
W3174691615 cites W2168647623 @default.
W3174691615 cites W2197572016 @default.
W3174691615 cites W2277484184 @default.
W3174691615 cites W2288878104 @default.
W3174691615 cites W2308840543 @default.
W3174691615 cites W2331749002 @default.
W3174691615 cites W2406128333 @default.
W3174691615 cites W2533620179 @default.
W3174691615 cites W2573789295 @default.
W3174691615 cites W2574119839 @default.
W3174691615 cites W2799510895 @default.
W3174691615 cites W2888419351 @default.
W3174691615 cites W2896638369 @default.
W3174691615 cites W2900783897 @default.
W3174691615 cites W2969747246 @default.
W3174691615 cites W3015935959 @default.
W3174691615 cites W4301052032 @default.
W3174691615 doi "https://doi.org/10.1016/j.jcmgh.2021.06.015" @default.
W3174691615 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8479479" @default.
W3174691615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34198013" @default.
W3174691615 hasPublicationYear "2021" @default.
W3174691615 type Work @default.
W3174691615 sameAs 3174691615 @default.
W3174691615 citedByCount "4" @default.
W3174691615 countsByYear W31746916152022 @default.
W3174691615 countsByYear W31746916152023 @default.
W3174691615 crossrefType "journal-article" @default.
W3174691615 hasAuthorship W3174691615A5002907035 @default.
W3174691615 hasAuthorship W3174691615A5010798854 @default.
W3174691615 hasAuthorship W3174691615A5062223587 @default.
W3174691615 hasAuthorship W3174691615A5064557742 @default.
W3174691615 hasAuthorship W3174691615A5073690542 @default.
W3174691615 hasAuthorship W3174691615A5073788764 @default.
W3174691615 hasBestOaLocation W31746916151 @default.
W3174691615 hasConcept C104317684 @default.
W3174691615 hasConcept C134018914 @default.
W3174691615 hasConcept C142724271 @default.
W3174691615 hasConcept C143065580 @default.
W3174691615 hasConcept C148738053 @default.
W3174691615 hasConcept C203014093 @default.
W3174691615 hasConcept C2778426112 @default.
W3174691615 hasConcept C2779134260 @default.
W3174691615 hasConcept C2780439177 @default.
W3174691615 hasConcept C2780942790 @default.
W3174691615 hasConcept C2781456731 @default.
W3174691615 hasConcept C54355233 @default.
W3174691615 hasConcept C66090201 @default.
W3174691615 hasConcept C71924100 @default.
W3174691615 hasConcept C86803240 @default.
W3174691615 hasConcept C95444343 @default.
W3174691615 hasConceptScore W3174691615C104317684 @default.
W3174691615 hasConceptScore W3174691615C134018914 @default.
W3174691615 hasConceptScore W3174691615C142724271 @default.
W3174691615 hasConceptScore W3174691615C143065580 @default.
W3174691615 hasConceptScore W3174691615C148738053 @default.
W3174691615 hasConceptScore W3174691615C203014093 @default.
W3174691615 hasConceptScore W3174691615C2778426112 @default.
W3174691615 hasConceptScore W3174691615C2779134260 @default.
W3174691615 hasConceptScore W3174691615C2780439177 @default.
W3174691615 hasConceptScore W3174691615C2780942790 @default.