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- W3174755326 abstract "Objectives: Based on our previous findings that dendritic cells (DC) are required to reveal epitopes of human herpesvirus 8 (KSHV/HHV8) glycoprotein B (gB) (Blood 99:3360, 2002), we determined CD8+ T cell responses to multiple lytic and latency viral proteins. Methods: T cells were stimulated with DC from HHV8 seropositive, HLA A*0201 donors that were loaded with overlapping peptides derived from gB and K8.1 lytic proteins, and K12 and LANA latency proteins, and screened for IFNγ production by ELISPOT. Positive peptides were then assessed for production of IFNγ, IL2, TNFα, MIP1β and CD107a by flow cytometry. Results: Our DC-T cell model revealed 5 gB, 4 K8.1, 2 K12 and 5 LANA HLA A*0201 epitopes. The HHV8 lytic and latency proteins induced predominately IFN-γ, IL2 and CD107a. Conclusions: This is the first demonstration that HHV8 lytic and latency proteins induce polycytokine production by CD8+ T cells. These targeted regions of the virus could be critical in HHV8 immunopathogenesis and vaccine development. (U01-AI35041, R01 CA82053)" @default.
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- W3174755326 date "2008-03-01" @default.
- W3174755326 modified "2023-09-25" @default.
- W3174755326 title "Polycytokine responses by CD8+ T lymphocytes to KSHV/HHV8 lytic and latency proteins" @default.
- W3174755326 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1068.3" @default.
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