Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174778648> ?p ?o ?g. }
- W3174778648 endingPage "244" @default.
- W3174778648 startingPage "236" @default.
- W3174778648 abstract "The objective of the current research to investigate the transdermal delivery of phytosomal Manjistha extract gel (MJE gel). The optimized formulation was prepared and evaluated for different parameters. MJE-loaded phytosomes were prepared by solvent evaporation method using rotary evaporator. The formulation was prepared with a variable concentration of lecithin (0.15–0.25% w/v), with stirring speed of the round bottom flask (80–160 rpm). Design expert software was used for the optimization of MJE-loaded phytosomal formulations. Central composite design-based factorial design was applied and evaluated for vesicular size and entrapment efficiency as dependent variables. The optimized formulation was further characterized with vesicle size, zeta potential, in vitro release. The Carbopol 934 was used to convert the phytosomal formulation (F10) into phytosomal gel and evaluated for ex vivo permeation to check the difference in permeation profile in compare to conventional MJE gel. The optimized MJE-loaded phytosomal formulation (F10) showed the vesicular size of 122.15 ± 3.73 nm, entrapment efficiency of 96.25 ± 2.45% with PDI value of 0.98 ± 0.06. Among the drug release kinetic models, the formulation followed the Higuchi model with drug release of 84.2 ± 4.1% in 12 h. Transmission electron micrograph showed the uniform structure and spherical shape. The prepared phytosomal gel shows prolonged release and enhanced permeation compared to conventional MJE gel." @default.
- W3174778648 created "2021-07-05" @default.
- W3174778648 creator A5004873742 @default.
- W3174778648 creator A5024154684 @default.
- W3174778648 creator A5030304491 @default.
- W3174778648 creator A5049718793 @default.
- W3174778648 creator A5078224748 @default.
- W3174778648 date "2021-06-28" @default.
- W3174778648 modified "2023-10-16" @default.
- W3174778648 title "Phytosomal gel of Manjistha extract (MJE) formulated and optimized with central composite design of Quality by Design (QbD)" @default.
- W3174778648 cites W1964522149 @default.
- W3174778648 cites W1994904293 @default.
- W3174778648 cites W1995753123 @default.
- W3174778648 cites W1999481657 @default.
- W3174778648 cites W2016251495 @default.
- W3174778648 cites W2018867583 @default.
- W3174778648 cites W2036850932 @default.
- W3174778648 cites W2044186731 @default.
- W3174778648 cites W2065491537 @default.
- W3174778648 cites W2119810330 @default.
- W3174778648 cites W2125927295 @default.
- W3174778648 cites W2154843269 @default.
- W3174778648 cites W2160760798 @default.
- W3174778648 cites W2250136834 @default.
- W3174778648 cites W2273780641 @default.
- W3174778648 cites W2286839548 @default.
- W3174778648 cites W2296971069 @default.
- W3174778648 cites W2345688875 @default.
- W3174778648 cites W2505448267 @default.
- W3174778648 cites W2611733388 @default.
- W3174778648 cites W2734929607 @default.
- W3174778648 cites W2783521908 @default.
- W3174778648 cites W2802824351 @default.
- W3174778648 cites W2884383626 @default.
- W3174778648 cites W2922074970 @default.
- W3174778648 cites W2967691925 @default.
- W3174778648 cites W2995738734 @default.
- W3174778648 cites W2997232303 @default.
- W3174778648 cites W3096650650 @default.
- W3174778648 cites W3100856180 @default.
- W3174778648 doi "https://doi.org/10.1080/01932691.2021.1942036" @default.
- W3174778648 hasPublicationYear "2021" @default.
- W3174778648 type Work @default.
- W3174778648 sameAs 3174778648 @default.
- W3174778648 citedByCount "7" @default.
- W3174778648 countsByYear W31747786482021 @default.
- W3174778648 countsByYear W31747786482022 @default.
- W3174778648 countsByYear W31747786482023 @default.
- W3174778648 crossrefType "journal-article" @default.
- W3174778648 hasAuthorship W3174778648A5004873742 @default.
- W3174778648 hasAuthorship W3174778648A5024154684 @default.
- W3174778648 hasAuthorship W3174778648A5030304491 @default.
- W3174778648 hasAuthorship W3174778648A5049718793 @default.
- W3174778648 hasAuthorship W3174778648A5078224748 @default.
- W3174778648 hasConcept C104779481 @default.
- W3174778648 hasConcept C105795698 @default.
- W3174778648 hasConcept C127413603 @default.
- W3174778648 hasConcept C150077022 @default.
- W3174778648 hasConcept C155672457 @default.
- W3174778648 hasConcept C159985019 @default.
- W3174778648 hasConcept C169222746 @default.
- W3174778648 hasConcept C171250308 @default.
- W3174778648 hasConcept C178790620 @default.
- W3174778648 hasConcept C185592680 @default.
- W3174778648 hasConcept C192562407 @default.
- W3174778648 hasConcept C205679159 @default.
- W3174778648 hasConcept C2776369308 @default.
- W3174778648 hasConcept C2779564620 @default.
- W3174778648 hasConcept C2780471494 @default.
- W3174778648 hasConcept C33923547 @default.
- W3174778648 hasConcept C41625074 @default.
- W3174778648 hasConcept C42360764 @default.
- W3174778648 hasConcept C43617362 @default.
- W3174778648 hasConcept C50670333 @default.
- W3174778648 hasConcept C55493867 @default.
- W3174778648 hasConcept C71924100 @default.
- W3174778648 hasConcept C86181022 @default.
- W3174778648 hasConcept C92397422 @default.
- W3174778648 hasConcept C98274493 @default.
- W3174778648 hasConceptScore W3174778648C104779481 @default.
- W3174778648 hasConceptScore W3174778648C105795698 @default.
- W3174778648 hasConceptScore W3174778648C127413603 @default.
- W3174778648 hasConceptScore W3174778648C150077022 @default.
- W3174778648 hasConceptScore W3174778648C155672457 @default.
- W3174778648 hasConceptScore W3174778648C159985019 @default.
- W3174778648 hasConceptScore W3174778648C169222746 @default.
- W3174778648 hasConceptScore W3174778648C171250308 @default.
- W3174778648 hasConceptScore W3174778648C178790620 @default.
- W3174778648 hasConceptScore W3174778648C185592680 @default.
- W3174778648 hasConceptScore W3174778648C192562407 @default.
- W3174778648 hasConceptScore W3174778648C205679159 @default.
- W3174778648 hasConceptScore W3174778648C2776369308 @default.
- W3174778648 hasConceptScore W3174778648C2779564620 @default.
- W3174778648 hasConceptScore W3174778648C2780471494 @default.
- W3174778648 hasConceptScore W3174778648C33923547 @default.
- W3174778648 hasConceptScore W3174778648C41625074 @default.
- W3174778648 hasConceptScore W3174778648C42360764 @default.
- W3174778648 hasConceptScore W3174778648C43617362 @default.