Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174812151> ?p ?o ?g. }
- W3174812151 endingPage "1165" @default.
- W3174812151 startingPage "1165" @default.
- W3174812151 abstract "Klebsiella pneumoniae is a rod-shaped, encapsulated, Gram-negative bacteria associated with multiple nosocomial infections. Multidrug-resistant (MDR) K. pneumoniae strains have been increasing and the therapeutic options are increasingly limited. Colistin is a long-used, polycationic, heptapeptide that has regained attention due to its activity against Gram-negative bacteria, including the MDR K. pneumoniae strains. However, this antibiotic has a complex mode of action that is still under research along with numerous side-effects. The acquisition of colistin resistance is mainly associated with alteration of lipid A net charge through the addition of cationic groups synthesized by the gene products of a multi-genic regulatory network. Besides mutations in these chromosomal genes, colistin resistance can also be achieved through the acquisition of plasmid-encoded genes. Nevertheless, the diversity of molecular markers for colistin resistance along with some adverse colistin properties compromises the reliability of colistin-resistance monitorization methods. The present review is focused on the colistin action and molecular resistance mechanisms, along with specific limitations on drug susceptibility testing for K. pneumoniae." @default.
- W3174812151 created "2021-07-05" @default.
- W3174812151 creator A5002119075 @default.
- W3174812151 creator A5014661338 @default.
- W3174812151 creator A5072231287 @default.
- W3174812151 date "2021-06-25" @default.
- W3174812151 modified "2023-10-14" @default.
- W3174812151 title "A Molecular Perspective on Colistin and Klebsiella pneumoniae: Mode of Action, Resistance Genetics, and Phenotypic Susceptibility" @default.
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