FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174813360> ?p ?o ?g. }

• W3174813360 endingPage "17284" @default.
• W3174813360 startingPage "17274" @default.
• W3174813360 abstract "The study was aimed at deciphering the function and mechanism of circ_0081001 in osteosarcoma (OS). In this study, quantitative real-time polymerase chain reaction (qRT-PCR) was utilized for quantifying circ_0081001, miR-494-3p, and BTB domain and CNC homolog 1 (BACH1) mRNA expressions in OS tissues and cells. Cell counting kit-8 (CCK-8) assay, together with 5-Ethynyl-2'-deoxyuridine (EdU) assay, was performed for evaluating cell proliferation; the alterations in apoptosis were analyzed utilizing flow cytometry; Transwell assay was conducted for examining cell migration and invasion; moreover, Western blot was utilized for the quantification of BACH1 protein expression; bioinformatics, dual-luciferase reporter gene, and RNA-binding protein immunoprecipitation assays were executed for validating the binding relationships between circ_0081001 and miR-494-3p, and between miR-494-3p and BACH1. As shown, circ_0081001, whose expression was elevated in OS tissues, had a negative association with miR-494-3p expression and a positive correlation with BACH1 expression. After circ_0081001 was overexpressed, the proliferation, migration, and invasion of OS cells were boosted but the apoptosis was reduced, whereas miR-494-3p exhibited opposite effects. The binding sites between circ_0081001 and miR-494-3p, and between miR-494-3p and the 3’UTR of BACH1 were experimentally verified. In conclusion, circ_0081001/miR-494-3p/BACH1 axis promoted the malignant biological behaviors of OS cells." @default.
• W3174813360 created "2021-07-05" @default.
• W3174813360 creator A5000891338 @default.
• W3174813360 creator A5000920972 @default.
• W3174813360 creator A5006233762 @default.
• W3174813360 creator A5009020949 @default.
• W3174813360 creator A5034694275 @default.
• W3174813360 creator A5036564630 @default.
• W3174813360 creator A5043735873 @default.
• W3174813360 creator A5076076028 @default.
• W3174813360 creator A5077068949 @default.
• W3174813360 date "2021-06-30" @default.
• W3174813360 modified "2023-10-15" @default.
• W3174813360 title "Circ_0081001 down-regulates miR-494-3p to enhance BACH1 expression and promotes osteosarcoma progression" @default.
• W3174813360 cites W2345553055 @default.
• W3174813360 cites W2617715606 @default.
• W3174813360 cites W2763547176 @default.
• W3174813360 cites W2777841932 @default.
• W3174813360 cites W2890477435 @default.
• W3174813360 cites W2895064298 @default.
• W3174813360 cites W2897881262 @default.
• W3174813360 cites W2904328481 @default.
• W3174813360 cites W2908944997 @default.
• W3174813360 cites W2953979824 @default.
• W3174813360 cites W2966576030 @default.
• W3174813360 cites W2967220881 @default.
• W3174813360 cites W2968299759 @default.
• W3174813360 cites W2972806461 @default.
• W3174813360 cites W2979522234 @default.
• W3174813360 cites W2983572435 @default.
• W3174813360 cites W2991636933 @default.
• W3174813360 cites W2992277018 @default.
• W3174813360 cites W2997525556 @default.
• W3174813360 cites W3003703235 @default.
• W3174813360 cites W3023027701 @default.
• W3174813360 cites W3028609354 @default.
• W3174813360 cites W3012536384 @default.
• W3174813360 doi "https://doi.org/10.18632/aging.203207" @default.
• W3174813360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8312427" @default.
• W3174813360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34191748" @default.
• W3174813360 hasPublicationYear "2021" @default.
• W3174813360 type Work @default.
• W3174813360 sameAs 3174813360 @default.
• W3174813360 citedByCount "6" @default.
• W3174813360 countsByYear W31748133602022 @default.
• W3174813360 countsByYear W31748133602023 @default.
• W3174813360 crossrefType "journal-article" @default.
• W3174813360 hasAuthorship W3174813360A5000891338 @default.
• W3174813360 hasAuthorship W3174813360A5000920972 @default.
• W3174813360 hasAuthorship W3174813360A5006233762 @default.
• W3174813360 hasAuthorship W3174813360A5009020949 @default.
• W3174813360 hasAuthorship W3174813360A5034694275 @default.
• W3174813360 hasAuthorship W3174813360A5036564630 @default.
• W3174813360 hasAuthorship W3174813360A5043735873 @default.
• W3174813360 hasAuthorship W3174813360A5076076028 @default.
• W3174813360 hasAuthorship W3174813360A5077068949 @default.
• W3174813360 hasBestOaLocation W31748133601 @default.
• W3174813360 hasConcept C104317684 @default.
• W3174813360 hasConcept C105580179 @default.
• W3174813360 hasConcept C153911025 @default.
• W3174813360 hasConcept C185592680 @default.
• W3174813360 hasConcept C190283241 @default.
• W3174813360 hasConcept C2776415932 @default.
• W3174813360 hasConcept C2777760704 @default.
• W3174813360 hasConcept C48023723 @default.
• W3174813360 hasConcept C502942594 @default.
• W3174813360 hasConcept C553184892 @default.
• W3174813360 hasConcept C55493867 @default.
• W3174813360 hasConcept C62112901 @default.
• W3174813360 hasConcept C86803240 @default.
• W3174813360 hasConceptScore W3174813360C104317684 @default.
• W3174813360 hasConceptScore W3174813360C105580179 @default.
• W3174813360 hasConceptScore W3174813360C153911025 @default.
• W3174813360 hasConceptScore W3174813360C185592680 @default.
• W3174813360 hasConceptScore W3174813360C190283241 @default.
• W3174813360 hasConceptScore W3174813360C2776415932 @default.
• W3174813360 hasConceptScore W3174813360C2777760704 @default.
• W3174813360 hasConceptScore W3174813360C48023723 @default.
• W3174813360 hasConceptScore W3174813360C502942594 @default.
• W3174813360 hasConceptScore W3174813360C553184892 @default.
• W3174813360 hasConceptScore W3174813360C55493867 @default.
• W3174813360 hasConceptScore W3174813360C62112901 @default.
• W3174813360 hasConceptScore W3174813360C86803240 @default.
• W3174813360 hasIssue "13" @default.
• W3174813360 hasLocation W31748133601 @default.
• W3174813360 hasLocation W31748133602 @default.
• W3174813360 hasOpenAccess W3174813360 @default.
• W3174813360 hasPrimaryLocation W31748133601 @default.
• W3174813360 hasRelatedWork W2253642286 @default.
• W3174813360 hasRelatedWork W2347266199 @default.
• W3174813360 hasRelatedWork W2351699250 @default.
• W3174813360 hasRelatedWork W2363247631 @default.
• W3174813360 hasRelatedWork W2381484265 @default.
• W3174813360 hasRelatedWork W2385346916 @default.
• W3174813360 hasRelatedWork W2387700717 @default.
• W3174813360 hasRelatedWork W2390532320 @default.
• W3174813360 hasRelatedWork W2431361778 @default.
• W3174813360 hasRelatedWork W3032118928 @default.

• next