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• W3174882914 abstract "Elastic fiber fragmentation (EFF) is a hallmark of aortic valve disease (AVD), and neovascularization has been identified as a late finding related to inflammation. We sought to characterize the relationship between early EFF and aberrant angiogenesis. To examine disease progression, regional anatomy and pathology of aortic valve tissue were assessed using histochemistry, immunohistochemistry, and electron microscopy from early-onset (<40 yo) and late-onset (≥40 yo) non-syndromic AVD specimens. To assess the effects of EFF on early AVD processes, valve tissue from Williams and Marfan syndrome patients was also analyzed. Bicuspid aortic valve was more common in early-onset AVD, and cardiovascular comorbidities were more common in late-onset AVD. Early-onset AVD specimens demonstrated angiogenesis without inflammation or atherosclerosis. A distinct pattern of elastic fiber components surrounded early-onset AVD neovessels, including increased emilin-1 and decreased fibulin-5. Different types of EFF were present in Williams syndrome (WS) and Marfan syndrome (MFS) aortic valves; WS but not MFS aortic valves demonstrated angiogenesis. Aberrant angiogenesis occurs in early-onset AVD in the absence of inflammation, implicating EFF. Elucidation of underlying mechanisms may inform the development of new pharmacologic treatments." @default.
• W3174882914 created "2021-07-05" @default.
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• W3174882914 date "2021-06-25" @default.
• W3174882914 modified "2023-10-14" @default.
• W3174882914 title "Early Aberrant Angiogenesis Due to Elastic Fiber Fragmentation in Aortic Valve Disease" @default.
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• W3174882914 doi "https://doi.org/10.3390/jcdd8070075" @default.
• W3174882914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8303641" @default.
• W3174882914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34202041" @default.
• W3174882914 hasPublicationYear "2021" @default.
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