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• W3174890578 abstract "Adaptive designs are gaining popularity in early phase clinical trials because they enable investigators to change the course of a study in response to accumulating data. We propose a novel design to simultaneously monitor several endpoints. These include efficacy, futility, toxicity and other outcomes in early phase, single-arm studies. We construct a recursive relationship to compute the exact probabilities of stopping for any combination of endpoints without the need for simulation, given pre-specified decision rules. The proposed design is flexible in the number and timing of interim analyses. A R Shiny app with user-friendly web interface has been created to facilitate the implementation of the proposed design." @default.
• W3174890578 created "2021-07-05" @default.
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• W3174890578 date "2021-06-23" @default.
• W3174890578 modified "2023-10-17" @default.
• W3174890578 title "Unified exact design with early stopping rules for single arm clinical trials with multiple endpoints" @default.
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• W3174890578 doi "https://doi.org/10.1177/09622802211013062" @default.
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