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• W3174927778 startingPage "346" @default.
• W3174927778 abstract "Central actions of dietary fructose advances obesity by promoting overfeeding. Dietary fructose (F) orchestrates concerted action from multiple interdependent and reciprocally-connected brain systems that are important for the control of feeding behavior. It increases the orexigenic drive to feed, and coupled with the loss of cortical inhibition, cravings can lead to feeding, which would otherwise be inhibited. These outcomes promote overfeeding and are exacerbated in obesity. • Fructose impairs metabolic and neurological processes to drive overfeeding. • Fructose increases orexigenic drive and promotes a hunger-like state in the brain. • Fructose intake increases the incentive salience of food leading to overfeeding. • Fructose-mediated cortical disinhibition increases impulsivity toward food reward. Fructose consumption has been linked with metabolic syndrome and obesity. Fructose-based sweeteners like high fructose corn syrup taste sweeter, improve food palatability, and are increasingly prevalent in our diet. The increase in fructose consumption precedes the rise in obesity and is a contributing driver to the obesity epidemic worldwide. The role of dietary fructose in obesity can be multifactorial by promoting visceral adiposity, hypertension, and insulin resistance. Interestingly, one emergent finding from human and animal studies is that dietary fructose promotes overfeeding. As the brain is a critical regulator of food intake, we reviewed the evidence that fructose can act in the brain and elucidated the major brain systems underlying fructose-induced overfeeding. We found that fructose acts on multiple interdependent brain systems to increase orexigenic drive and the incentive salience of food while decreasing the latency between food bouts and reducing cognitive control to disinhibit feeding. We concluded that the collective actions of fructose may promote feeding behavior by producing a hunger-like state in the brain." @default.
• W3174927778 created "2021-07-05" @default.
• W3174927778 creator A5010229707 @default.
• W3174927778 creator A5064255233 @default.
• W3174927778 date "2021-09-01" @default.
• W3174927778 modified "2023-09-29" @default.
• W3174927778 title "Neural mechanisms underlying the role of fructose in overfeeding" @default.
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