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- W3174934923 abstract "Excitation neurotoxicity induced dysregulation of stress response signaling has been implicated in neurodegenerative pathologies such as Alzheimer's disease and Parkinson's disease. Cinnamon was previously reported to beneficially modulate stress response signaling in C. elegans and may have therapeutic potential. The objective here was to evaluate the dose dependent neuroprotective effect of cinnamon on L-glutamate and NDMA induced excitation toxicity in cultured primary neurons from chick embryos. Results suggest that cinnamon treatment decreased neuronal cell death in L-glutamate and NDMA induced excitation toxicity by 20% and 15% respectively. Evaluation with fractionated cinnamon extract characterized by HPLC/DAD/ELSD/MS suggests that protection against L-glutamate toxicity was primarily due to the polar neutral fraction which increased neuronal cell survival by 23%. Neuroprotective effects in NDMA treated primary cultures were predominantly due to polar basic fraction which decreased cell death by 25% compared to control. Grant Funding Source: VRDÜR Foundation" @default.
- W3174934923 created "2021-07-05" @default.
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- W3174934923 date "2012-04-01" @default.
- W3174934923 modified "2023-09-26" @default.
- W3174934923 title "Cinnamon decreases excitation toxicity in primary neuronal cultures from chick embryos" @default.
- W3174934923 doi "https://doi.org/10.1096/fasebj.26.1_supplement.1025.11" @default.
- W3174934923 hasPublicationYear "2012" @default.
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