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- W3174935088 abstract "The nitrogen catabolite repression (NCR) pathway is involved in nitrogen utilization, in which the global GATA transcription factor AreA plays an indispensable role and has been reported in many fungi. However, relatively few studies are focused on AreB, another GATA transcription factor in the NCR pathway and the functions of AreB are largely unknown in entomopathogenic fungi. Here, we characterized MaAreB in the model entomopathogenic fungus Metarhizium acridum. Sequence arrangement found that MaAreB had a conserved GATA zinc finger DNA binding domain and a leucine zipper domain. Disruption of MaAreB affected the nitrogen utilization and led to decelerated conidial germination and hyphal growth, decreased conidial yield, and lower tolerances to UV-B irradiation and heat-shock. Furthermore, the MaAreB mutant (ΔMaAreB) exhibited increased sensitivity to CFW (Calcofluor white), decreased cell wall contents (chitin and β-1,3-glucan) and reduced expression levels of some genes related to cell wall integrity, indicating that disruption of MaAreB affected the cell wall integrity. Bioassays showed that the virulence of the ΔMaAreB strain was decreased in topical inoculation but not in intra-hemocoel injection. Consistently, deletion of MaAreB severely impaired the appressorium formation and reduced the turgor pressure of appressorium. These results revealed that MaAreB regulated fungal nitrogen utilization, cell wall integrity and biological control potential, which would contribute to the functional characterization of AreB homologous proteins in other insect fungal pathogens, and even filamentous fungi." @default.
- W3174935088 created "2021-07-05" @default.
- W3174935088 creator A5021851832 @default.
- W3174935088 creator A5034407476 @default.
- W3174935088 creator A5062766009 @default.
- W3174935088 creator A5084078757 @default.
- W3174935088 date "2021-06-27" @default.
- W3174935088 modified "2023-09-26" @default.
- W3174935088 title "MaAreB, a GATA Transcription Factor, Is Involved in Nitrogen Source Utilization, Stress Tolerances and Virulence in Metarhizium acridum" @default.
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- W3174935088 doi "https://doi.org/10.3390/jof7070512" @default.
- W3174935088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8305397" @default.
- W3174935088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34198996" @default.
- W3174935088 hasPublicationYear "2021" @default.
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