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- W3174953800 startingPage "7285" @default.
- W3174953800 abstract "Flavones are an important class of bioactive constituents in foods, and their structural diversity enables them to interact with different targets. In particular, flavones are known for their anti-inflammatory activity. Herein, we summarized commonly applied in vitro, in vivo, and clinical models in testing anti-inflammatory activity of flavones. The anti-inflammatory structure–activity relationship of flavones was systematically mapped and supported with cross comparisons of that with flavanones, flavanols, and isoflavones. Hydroxyl groups (−OH) are indispensable for the anti-inflammatory function of flavones, and −OH at the C-5 and C-4′ positions enhance while −OH at the C-6, C-7, C-8, and C-3′ positions attenuate their activity. Moreover, the C2–C3 single bond, −OH at the C-3 and B-ring positions undermine flavone aglycones’ activity. Most of the flavone aglycones function through NF-κB, MAPK, and JNK-STAT pathways, and their possible cell binding targets are kinase, aryl hydrocarbon receptor (AhR), G-protein coupled receptors, and estrogen receptors. However, the structure and anti-inflammatory activity relationship of flavones were unclear, and further research shall be conducted to close the gap in order to guide development of evidence-based functional foods." @default.
- W3174953800 created "2021-07-05" @default.
- W3174953800 creator A5004635944 @default.
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- W3174953800 creator A5023648511 @default.
- W3174953800 creator A5034002217 @default.
- W3174953800 creator A5044936528 @default.
- W3174953800 date "2021-06-23" @default.
- W3174953800 modified "2023-10-14" @default.
- W3174953800 title "Anti-Inflammation Activity of Flavones and Their Structure–Activity Relationship" @default.
- W3174953800 cites W1273009769 @default.
- W3174953800 cites W1483601276 @default.
- W3174953800 cites W1589605106 @default.
- W3174953800 cites W1914622032 @default.
- W3174953800 cites W1965564902 @default.
- W3174953800 cites W1967384334 @default.
- W3174953800 cites W1968446968 @default.
- W3174953800 cites W1972715563 @default.
- W3174953800 cites W1976871989 @default.
- W3174953800 cites W1984235159 @default.
- W3174953800 cites W1984422122 @default.
- W3174953800 cites W1985812680 @default.
- W3174953800 cites W1990164787 @default.
- W3174953800 cites W1990421417 @default.
- W3174953800 cites W1990657948 @default.
- W3174953800 cites W1992444004 @default.
- W3174953800 cites W1992895936 @default.
- W3174953800 cites W1995377160 @default.
- W3174953800 cites W1999718336 @default.
- W3174953800 cites W2001202753 @default.
- W3174953800 cites W2004349171 @default.
- W3174953800 cites W2004471429 @default.
- W3174953800 cites W2005219907 @default.
- W3174953800 cites W2008274402 @default.
- W3174953800 cites W2018220404 @default.
- W3174953800 cites W2019060471 @default.
- W3174953800 cites W2025410841 @default.
- W3174953800 cites W2029958298 @default.
- W3174953800 cites W2031034395 @default.
- W3174953800 cites W2031690762 @default.
- W3174953800 cites W2033029602 @default.
- W3174953800 cites W2038017065 @default.
- W3174953800 cites W2038433879 @default.
- W3174953800 cites W2038758843 @default.
- W3174953800 cites W2039625808 @default.
- W3174953800 cites W2043520637 @default.
- W3174953800 cites W2045277541 @default.
- W3174953800 cites W2049241173 @default.
- W3174953800 cites W2054633072 @default.
- W3174953800 cites W2066854119 @default.
- W3174953800 cites W2070292315 @default.
- W3174953800 cites W2071959445 @default.
- W3174953800 cites W2074513035 @default.
- W3174953800 cites W2077459776 @default.
- W3174953800 cites W2077763928 @default.
- W3174953800 cites W2088548720 @default.
- W3174953800 cites W2099784932 @default.
- W3174953800 cites W2102715783 @default.
- W3174953800 cites W2111797455 @default.
- W3174953800 cites W2118910625 @default.
- W3174953800 cites W2120532705 @default.
- W3174953800 cites W2121325621 @default.
- W3174953800 cites W2122355853 @default.
- W3174953800 cites W2140942440 @default.
- W3174953800 cites W2141690002 @default.
- W3174953800 cites W2142463490 @default.
- W3174953800 cites W2159949408 @default.
- W3174953800 cites W2161386296 @default.
- W3174953800 cites W2164315310 @default.
- W3174953800 cites W2166689150 @default.
- W3174953800 cites W2170433252 @default.
- W3174953800 cites W2171223017 @default.
- W3174953800 cites W2171880801 @default.
- W3174953800 cites W2172047505 @default.
- W3174953800 cites W223345270 @default.
- W3174953800 cites W2289930909 @default.
- W3174953800 cites W2297606889 @default.
- W3174953800 cites W2312937577 @default.
- W3174953800 cites W2314797279 @default.
- W3174953800 cites W2315152171 @default.
- W3174953800 cites W2346348297 @default.
- W3174953800 cites W2394948717 @default.
- W3174953800 cites W2413884547 @default.
- W3174953800 cites W2418137623 @default.
- W3174953800 cites W2506002793 @default.
- W3174953800 cites W2509554038 @default.
- W3174953800 cites W2524259179 @default.
- W3174953800 cites W2529645095 @default.
- W3174953800 cites W2562957617 @default.
- W3174953800 cites W2565383127 @default.
- W3174953800 cites W2608842151 @default.
- W3174953800 cites W261647878 @default.
- W3174953800 cites W2621256009 @default.
- W3174953800 cites W2737836704 @default.
- W3174953800 cites W2740601290 @default.
- W3174953800 cites W2752981360 @default.
- W3174953800 cites W2761210135 @default.