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• W3175018851 abstract "The size of the transcriptional program of long non-coding RNAs in the mammalian genome has engendered discussions about their biological roles1, particularly the promoter antisense (PAS) transcripts2,3. Here we report the development of an assay—referred to as chromatin isolation by RNA–Cas13a complex—to quantitatively detect the distribution of RNA in the genome. The assay revealed that PAS RNAs serve as a key gatekeeper of a broad transcriptional pause release program, based on decommissioning the 7SK small nuclear RNA-dependent inhibitory P-TEFb complex. Induction of PAS RNAs by liganded ERα led to a significant loss of H3K9me3 and the release of basally recruited HP1α and KAP1 on activated target gene promoters. This release was due to PAS RNA-dependent recruitment of H3K9me3 demethylases, which required interactions with a compact stem-loop structure in the PAS RNAs, an apparent feature of similarly regulated PAS RNAs. Activation of the ERα-bound MegaTrans enhancer, which is essential for robust pause release, required the recruitment of phosphorylated KAP1, with its transfer to the cognate promoters permitting 17β-oestradiol-induced pause release and activation of the target gene. This study reveals a mechanism, based on RNA structure, that mediates the function of PAS RNAs in gene regulation. The authors describe a role for the non-coding antisense transcripts produced at promoters in regulating ligand-induced activation of gene transcription." @default.
• W3175018851 created "2021-07-05" @default.
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• W3175018851 date "2021-06-30" @default.
• W3175018851 modified "2023-10-16" @default.
• W3175018851 title "Shape of promoter antisense RNAs regulates ligand-induced transcription activation" @default.
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• W3175018851 doi "https://doi.org/10.1038/s41586-021-03589-x" @default.
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