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- W3175025765 abstract "The role of acid-sensing channels during the normal function of the nervous system is poorly defined. Pickpocket1, PPK1, is a DEG/ENaC homolog restrictively expressed in Drosophila class IV multidentritic (md) sensory neurons. These channels are believed to be involved in sensory proprioception, but an exact mechanism is undefined. Using a primary neuronal culture from Drosophila embryos and whole cell patch-clamping, we identify amiloride-sensitive sustained (Is) and transient (It) acid-sensing Na+ currents in md neurons. The robust sustained pH-sensitive current is Na+ and K+-selective and sensitive to amiloride but refractory to ruthenium red. A distinct transient sodium current is revealed by relief from inhibition following extracellular acidification. This transient pH-sensitive current is absent in ppk1 −/− flies and rescued by targeted expression of a PPK1-transgene identifying it as the PPK1 current. PPK1 function in md sensory neurons is necessary for normal Drosophila larvae proprioception consistent with PPK1 functioning as a molecular mechanosensory transducer. PPK1 activity is not required for intrinsic excitability but rather transduces dynamic sensory input essential to proprioception." @default.
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- W3175025765 date "2012-04-01" @default.
- W3175025765 modified "2023-09-23" @default.
- W3175025765 title "Pickpocket1 is a Drosophila Acid‐Sensing Na + Channel Necessary for Proprioception" @default.
- W3175025765 doi "https://doi.org/10.1096/fasebj.26.1_supplement.695.19" @default.
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