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- W3175080509 abstract "Colorectal adenomas are considered as precursors of colorectal cancer. B-vitamins (i.e., folate, vitamin B-6 and B-12) involve in the homocysteine metabolism and play as coenzymes in one-carbon metabolism, which may have a critical role in the colorectal polyps progression. The purpose of this study was to examine the effects of B-vitamins and homocysteine on the risk of colorectal polyps. This study was an observational case-control design. Forty-seven subjects with colorectal polyps [29 adenomatous polyps (AP), 18 hyperplastic polyps (HP)] and 95 age-, sex-matched healthy subjects were recruited. Subjects with AP and HP had significantly higher plasma homocysteine levels than did healthy subjects. There was no significant difference in serum folate and vitamin B-12 and plasma pyridoxal 5′-phosphate among the three groups. B-vitamins had no significant effect on the risk of colorectal polyps. However, subjects with higher plasma homocysteine (OR, 2.18; 95% CI, 1.23 – 3.88) level exhibited significantly increased risk of colorectal polyps after body mass index, diastolic blood pressure, total cholesterol and B-vitamins were additionally adjusted. Plasma homocysteine, but not B-vitamins, is a strong predictor of the risk of colorectal polyps while subjects had adequate B-vitamins status. This study was supported by National Science Council (NSC 97-2320-B-040-031-MY3), Taiwan." @default.
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- W3175080509 date "2011-04-01" @default.
- W3175080509 modified "2023-09-27" @default.
- W3175080509 title "Higher plasma homocysteine is associated with increased risk of colorectal polyps" @default.
- W3175080509 doi "https://doi.org/10.1096/fasebj.25.1_supplement.978.8" @default.
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