Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175092238> ?p ?o ?g. }
- W3175092238 endingPage "605" @default.
- W3175092238 startingPage "595" @default.
- W3175092238 abstract "Gastric cancer is a common lethal malignancy and causes great cancer-related mortality worldwide. MicroRNA (miR)-328-3p is implicated in the progression of various human cancers; however, its role and mechanism in the progression of gastric cancer remain unclear.Human gastric cancer cells were incubated with miR-328-3p mimic, inhibitor or the matched negative control. Cell viability, colony formation, migrative and invasive capacity, cell apoptosis and oxidative stress were measured. To clarify the involvement of nuclear factor-E2-related factor 2 (NRF2) and kelch-like ECH-associated protein 1 (KEAP1), small interfering RNA was used. miR-328-3p was upregulated in human gastric cancer cells and tissues, and its level positively correlated with the progression of gastric cancer. miR-328-3p promoted cell viability, colony formation, migration and invasion, thereby facilitating the progression of gastric cancer. miR-328-3p mimic reduced, while miR-328-3p inhibitor increased apoptosis and oxidative stress of human gastric cancer cells. Mechanistically, miR-328-3p upregulated NRF2 via targeting KEAP1to attenuate excessive free radical production and cell apoptosis. miR-328-3p functions as an oncogenic gene and inhibiting miR-328-3p may help to develop novel therapeutic strategies of human gastric cancer." @default.
- W3175092238 created "2021-07-05" @default.
- W3175092238 creator A5006001591 @default.
- W3175092238 creator A5007923079 @default.
- W3175092238 creator A5013328731 @default.
- W3175092238 creator A5015082378 @default.
- W3175092238 creator A5024305165 @default.
- W3175092238 creator A5050824975 @default.
- W3175092238 creator A5062520476 @default.
- W3175092238 date "2021-06-03" @default.
- W3175092238 modified "2023-10-07" @default.
- W3175092238 title "MicroRNA-328-3p facilitates the progression of gastric cancer via KEAP1/NRF2 axis" @default.
- W3175092238 cites W2118422955 @default.
- W3175092238 cites W2154054213 @default.
- W3175092238 cites W2190893384 @default.
- W3175092238 cites W2210422289 @default.
- W3175092238 cites W2729783724 @default.
- W3175092238 cites W2738348371 @default.
- W3175092238 cites W2767950945 @default.
- W3175092238 cites W2794318176 @default.
- W3175092238 cites W2799290037 @default.
- W3175092238 cites W2808485929 @default.
- W3175092238 cites W2891777345 @default.
- W3175092238 cites W2896591936 @default.
- W3175092238 cites W2898548375 @default.
- W3175092238 cites W2898592197 @default.
- W3175092238 cites W2898640480 @default.
- W3175092238 cites W2902549824 @default.
- W3175092238 cites W2904480884 @default.
- W3175092238 cites W2905929082 @default.
- W3175092238 cites W2908988364 @default.
- W3175092238 cites W2911182175 @default.
- W3175092238 cites W2912123613 @default.
- W3175092238 cites W2913633759 @default.
- W3175092238 cites W2916543168 @default.
- W3175092238 cites W2920988119 @default.
- W3175092238 cites W2952024021 @default.
- W3175092238 cites W2952484942 @default.
- W3175092238 cites W2971379494 @default.
- W3175092238 cites W2980708979 @default.
- W3175092238 cites W2981854755 @default.
- W3175092238 cites W2984747734 @default.
- W3175092238 cites W2995966466 @default.
- W3175092238 cites W3005238899 @default.
- W3175092238 cites W3006975085 @default.
- W3175092238 cites W3007586596 @default.
- W3175092238 cites W3011855728 @default.
- W3175092238 cites W3015949790 @default.
- W3175092238 cites W3037136076 @default.
- W3175092238 cites W3039762833 @default.
- W3175092238 cites W3040069469 @default.
- W3175092238 cites W3041725004 @default.
- W3175092238 cites W3044129371 @default.
- W3175092238 cites W3048138702 @default.
- W3175092238 cites W3048263756 @default.
- W3175092238 cites W3050682578 @default.
- W3175092238 cites W3082718748 @default.
- W3175092238 cites W3084030640 @default.
- W3175092238 cites W3087603649 @default.
- W3175092238 cites W3091929989 @default.
- W3175092238 cites W3091964206 @default.
- W3175092238 cites W3092085980 @default.
- W3175092238 cites W3092149586 @default.
- W3175092238 cites W3092217910 @default.
- W3175092238 cites W3092884609 @default.
- W3175092238 cites W3093524988 @default.
- W3175092238 cites W3093919307 @default.
- W3175092238 cites W3096349239 @default.
- W3175092238 cites W3101711825 @default.
- W3175092238 cites W3101966691 @default.
- W3175092238 cites W3109533492 @default.
- W3175092238 cites W3110812876 @default.
- W3175092238 cites W3111747876 @default.
- W3175092238 cites W3113203979 @default.
- W3175092238 cites W3113913409 @default.
- W3175092238 cites W3121564244 @default.
- W3175092238 cites W3123860404 @default.
- W3175092238 cites W3125677941 @default.
- W3175092238 doi "https://doi.org/10.1080/10715762.2021.1923705" @default.
- W3175092238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34160338" @default.
- W3175092238 hasPublicationYear "2021" @default.
- W3175092238 type Work @default.
- W3175092238 sameAs 3175092238 @default.
- W3175092238 citedByCount "7" @default.
- W3175092238 countsByYear W31750922382022 @default.
- W3175092238 countsByYear W31750922382023 @default.
- W3175092238 crossrefType "journal-article" @default.
- W3175092238 hasAuthorship W3175092238A5006001591 @default.
- W3175092238 hasAuthorship W3175092238A5007923079 @default.
- W3175092238 hasAuthorship W3175092238A5013328731 @default.
- W3175092238 hasAuthorship W3175092238A5015082378 @default.
- W3175092238 hasAuthorship W3175092238A5024305165 @default.
- W3175092238 hasAuthorship W3175092238A5050824975 @default.
- W3175092238 hasAuthorship W3175092238A5062520476 @default.
- W3175092238 hasConcept C104317684 @default.
- W3175092238 hasConcept C121608353 @default.
- W3175092238 hasConcept C126322002 @default.
- W3175092238 hasConcept C127561419 @default.