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- W3175113283 abstract "Lujo virus (LUJV), a highly pathogenic arenavirus, was first identified in 2008 in Zambia. To aid the identification of effective therapeutics for LUJV, we developed a recombinant reporter virus system, confirming reporter LUJV comparability with wild-type virus and its utility in high-throughput antiviral screening assays. Using this system, we evaluated compounds with known and unknown efficacy against related arenaviruses, with the aim of identifying LUJV-specific and potential new pan-arenavirus antivirals. We identified six compounds demonstrating robust anti-LUJV activity, including several compounds with previously reported activity against other arenaviruses. These data provide critical evidence for developing broad-spectrum antivirals against high-consequence arenaviruses." @default.
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- W3175113283 date "2021-06-28" @default.
- W3175113283 modified "2023-10-03" @default.
- W3175113283 title "Screening and Identification of Lujo Virus Inhibitors Using a Recombinant Reporter Virus Platform" @default.
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- W3175113283 doi "https://doi.org/10.3390/v13071255" @default.
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