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• W3175128051 abstract "Cerebral blood flow (CBF) autoregulation is a robust protective mechanism that maintains constant blood flow during changes in perfusion pressure. Although it is well known that major cardiovascular adaptations occur during normal pregnancies, the cerebral vascular adaptations that occur during pregnancy, especially in the setting of hypertensive pregnancies, are poorly understood. Hypertension is typically associated with normal autoregulatory function in the cerebral circulation, although the upper and lower limits of the autoregulatory curve are shifted to higher blood pressures. Previous studies in pregnant Sprague Dawley (SD) rats show that the cerebral autoregulatory curve is shifted to higher pressures compared to nonpregnant rats. The impact of preexisting hypertension on cerebral blood flow autoregulation has not been examined. The current study was performed to test the hypothesis that CBF autoregulation is impaired during pregnancy in the presence of underlying hypertension. Dahl salt-sensitive (Dahl S) and spontaneously hypertensive (SHR) rats, 19–22 weeks of age, were used because they spontaneously develop hypertension without additional challenges. Female rats were mated with same strain males, and gestational day 1 (G1) of pregnancy was defined by the detection of sperm histologically from a vaginal swab. CBF was assessed on G18–20 in rats anesthetized with Inactin. Briefly, catheters were placed in the femoral artery and vein to monitor blood pressure and continuously and administer phenylephrine, respectively. Laser Doppler flow probes were positioned above two closed cranial windows 3–4 mm lateral and 2mm distal to Bregma to assess relative changes in CBF in response to increases in blood pressure. Linear regression analysis of CBF autoregulatory curves shows significant differences between pregnant and virgin rats across strains (★★, p<0.0001) and between strains in the pregnant rats (★★, p<0.0001, Figure). No significant differences in slopes were observed between strains in the virgin rats. Contrary to our hypothesis, these data show that CBF autoregulation was enhanced during pregnancy in two different models of spontaneous hypertension. Previous studies from our laboratory showed increased vascular and blood brain barrier permeability in pregnant Dahl S rats when compared to virgin littermates. Therefore, these data suggest an uncoupling of cerebral vascular permeability from CBF autoregulation in this model of superimposed preeclampsia. Future studies will investigate the role of pregnancy specific circulating factors that contribute to these changes and their implications on cerebrovascular function. Support or Funding Information KJM was supported by 5T32HL105324-09. Work was supported by 1R01HL137673 to MRG, HL136684to MJR, and R01HL134711 to JMS. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal." @default.
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• W3175128051 date "2019-04-01" @default.
• W3175128051 modified "2023-09-26" @default.
• W3175128051 title "Cerebral Blood Flow Autoregulation in Hypertensive Models of Pregnancy" @default.
• W3175128051 doi "https://doi.org/10.1096/fasebj.2019.33.1_supplement.865.1" @default.
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