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- W3175133095 abstract "Abstract The quantitative detection of cancer cells and the evaluation of folate receptor (FR) expression on cell membranes are of great significance for tumor‐related research. In this work, a photoelectrochemical (PEC) biosensing interface is proposed for detection of cancer cells based on the construction of nanostructured platforms coupled with surface engineering. A “sphere‐on‐tube” hierarchical nanostructure is fabricated by depositing biomimetic polydopamine nanospheres on TiO 2 nanotube arrays. Enhanced PEC responses are achieved with the formation of polyethylene glycol antifouling layers and the immobilization of folic acid as a recognition ligand. Based on the ligand–receptor interaction, the antifouling PEC biosensor exhibits a wide linear range for the detection of the breast cancer cell line MDA‐MB‐231 from 20 to 2.0 × 10 6 cells mL −1 with a low detection limit of 15 cells mL −1 (S/N = 3). The expressing differentiation of FR on several cancer cells is well discriminated. The proposed PEC cytosensing method shows great potential in detection of cancer cells expressing folate receptors." @default.
- W3175133095 created "2021-07-05" @default.
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- W3175133095 date "2021-06-21" @default.
- W3175133095 modified "2023-10-17" @default.
- W3175133095 title "Sphere‐on‐Tube Biomimetic Hierarchical Nanostructures Coupled with Engineered Surfaces for Enhanced Photoelectrochemical Biosensing of Cancer Cells Expressing Folate Receptors" @default.
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- W3175133095 doi "https://doi.org/10.1002/admi.202100421" @default.
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