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- W3175148300 abstract "Obese Zucker rats (OZR) are mildly hypertensive with a chronically elevated sympathetic vasomotor tone compared to lean Zucker rats (LZR). The OZR have reduced sympathetic responses to hypertension and hypotension, suggesting impaired baroreflexes. In contrast, OZR have exaggerated sympatho-excitatory (S-E) and pressor responses to other stimuli. To determine whether the exaggerated S-E responses are the consequence of an inability to buffer the simultaneous increase in arterial pressure, we examined S-E responses in the absence of accompanying pressor responses. Six age-matched OZR and LZR were anesthetized with urethane (0.64±0.004 g, iv), ventilated, and paralyzed and subjected to stimulation of sciatic nerve and the diving reflex. After blockade of alpha-adrenergic receptors (phentolamine, 10 mg/kg) and beta-adrenergic receptors (propranolol, 5 mg/kg) to prevent sympathetically-mediated pressor responses, OZR still had exaggerated splanchnic nerve responses to stimulation of sciatic nerve (600 microA, 33Hz, 5 sec; 144% vs. 115%, p <0.05) and diving reflex (130% vs. 119%). These data suggest OZR have a baroreflex-independent augmentation of sympatho-excitatory responses. Supported by NIH: RO1 HL075174." @default.
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- W3175148300 date "2006-03-01" @default.
- W3175148300 modified "2023-09-24" @default.
- W3175148300 title "Baroreceptor‐independent augmented sympatho‐excitatory responses in obese Zucker rats" @default.
- W3175148300 doi "https://doi.org/10.1096/fasebj.20.4.a771-d" @default.
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