FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175150437> ?p ?o ?g. }

• W3175150437 abstract "Management of breast cancer in limited-resource settings is hindered by a lack of low-cost, logistically sustainable approaches toward molecular and cellular diagnostic pathology services that are needed to guide therapy. To address these limitations, we have developed a multimodal cellphone-based platform-the EpiView-D4-that can evaluate both cellular morphology and molecular expression of clinically relevant biomarkers directly from fine-needle aspiration (FNA) of breast tissue specimens within 1 h. The EpiView-D4 is comprised of two components: (1) an immunodiagnostic chip built upon a non-fouling polymer brush-coating (the D4) which quantifies expression of protein biomarkers directly from crude cell lysates, and (2) a custom cellphone-based optical microscope (EpiView) designed for imaging cytology preparations and D4 assay readout. As a proof-of-concept, we used the EpiView-D4 for assessment of human epidermal growth factor receptor-2 (HER2) expression and validated the performance using cancer cell lines, animal models, and human tissue specimens. We found that FNA cytology specimens (prepared in less than 5 min with rapid staining kits) imaged by the EpiView-D4 were adequate for assessment of lesional cellularity and tumor content. We also found our device could reliably distinguish between HER2 expression levels across multiple different cell lines and animal xenografts. In a pilot study with human tissue (n = 19), we were able to accurately categorize HER2-negative and HER2-positve tumors from FNA specimens. Taken together, the EpiView-D4 offers a promising alternative to invasive-and often unavailable-pathology services and may enable the democratization of effective breast cancer management in limited-resource settings." @default.
• W3175150437 created "2021-07-05" @default.
• W3175150437 creator A5000501007 @default.
• W3175150437 creator A5001678411 @default.
• W3175150437 creator A5013312737 @default.
• W3175150437 creator A5016887928 @default.
• W3175150437 creator A5032614083 @default.
• W3175150437 creator A5037408779 @default.
• W3175150437 creator A5044808527 @default.
• W3175150437 creator A5044943844 @default.
• W3175150437 creator A5051895132 @default.
• W3175150437 creator A5055323364 @default.
• W3175150437 creator A5061721402 @default.
• W3175150437 creator A5063316703 @default.
• W3175150437 creator A5071404449 @default.
• W3175150437 creator A5072976618 @default.
• W3175150437 creator A5076344748 @default.
• W3175150437 creator A5077702152 @default.
• W3175150437 creator A5083193232 @default.
• W3175150437 creator A5086163310 @default.
• W3175150437 date "2021-07-02" @default.
• W3175150437 modified "2023-10-10" @default.
• W3175150437 title "Cellphone enabled point-of-care assessment of breast tumor cytology and molecular HER2 expression from fine-needle aspirates" @default.
• W3175150437 cites W1568084954 @default.
• W3175150437 cites W1961026612 @default.
• W3175150437 cites W1963538258 @default.
• W3175150437 cites W1964033473 @default.
• W3175150437 cites W1966562377 @default.
• W3175150437 cites W1973260880 @default.
• W3175150437 cites W1975716486 @default.
• W3175150437 cites W1975964036 @default.
• W3175150437 cites W1982846895 @default.
• W3175150437 cites W1984133159 @default.
• W3175150437 cites W1996778928 @default.
• W3175150437 cites W1998914462 @default.
• W3175150437 cites W2001221914 @default.
• W3175150437 cites W2011687187 @default.
• W3175150437 cites W2019668643 @default.
• W3175150437 cites W2026895395 @default.
• W3175150437 cites W2027711745 @default.
• W3175150437 cites W2028215068 @default.
• W3175150437 cites W2028222070 @default.
• W3175150437 cites W2030085511 @default.
• W3175150437 cites W2040935952 @default.
• W3175150437 cites W2060966049 @default.
• W3175150437 cites W2068809896 @default.
• W3175150437 cites W2071399585 @default.
• W3175150437 cites W2072228651 @default.
• W3175150437 cites W2072391825 @default.
• W3175150437 cites W2088060713 @default.
• W3175150437 cites W2097937370 @default.
• W3175150437 cites W2099351704 @default.
• W3175150437 cites W2102956462 @default.
• W3175150437 cites W2110827195 @default.
• W3175150437 cites W2115759102 @default.
• W3175150437 cites W2121564425 @default.
• W3175150437 cites W2124188012 @default.
• W3175150437 cites W2131414785 @default.
• W3175150437 cites W2142361813 @default.
• W3175150437 cites W2144124503 @default.
• W3175150437 cites W2144549147 @default.
• W3175150437 cites W2146384083 @default.
• W3175150437 cites W2149908785 @default.
• W3175150437 cites W2152121590 @default.
• W3175150437 cites W2159459001 @default.
• W3175150437 cites W2166656480 @default.
• W3175150437 cites W2177960969 @default.
• W3175150437 cites W2207280197 @default.
• W3175150437 cites W2222638000 @default.
• W3175150437 cites W2254290662 @default.
• W3175150437 cites W2318102414 @default.
• W3175150437 cites W2318605753 @default.
• W3175150437 cites W2340007672 @default.
• W3175150437 cites W2416458263 @default.
• W3175150437 cites W2437556100 @default.
• W3175150437 cites W2484275760 @default.
• W3175150437 cites W2508974650 @default.
• W3175150437 cites W2511064907 @default.
• W3175150437 cites W2544526123 @default.
• W3175150437 cites W2560234483 @default.
• W3175150437 cites W2578583446 @default.
• W3175150437 cites W257908793 @default.
• W3175150437 cites W2580767461 @default.
• W3175150437 cites W2599086938 @default.
• W3175150437 cites W2606471537 @default.
• W3175150437 cites W2744588570 @default.
• W3175150437 cites W2745239534 @default.
• W3175150437 cites W2759686876 @default.
• W3175150437 cites W2774986603 @default.
• W3175150437 cites W2785110871 @default.
• W3175150437 cites W2883653581 @default.
• W3175150437 cites W2909146242 @default.
• W3175150437 cites W2912508873 @default.
• W3175150437 cites W2917837889 @default.
• W3175150437 cites W2945807221 @default.
• W3175150437 cites W2953197682 @default.
• W3175150437 cites W2989984014 @default.
• W3175150437 cites W2997232478 @default.
• W3175150437 cites W2998175747 @default.
• W3175150437 cites W3004659673 @default.

• next