FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175202389> ?p ?o ?g. }

• W3175202389 endingPage "100093" @default.
• W3175202389 startingPage "100093" @default.
• W3175202389 abstract "The liver is the central organ regulating cholesterol synthesis, storage, transport, and elimination. Mouse carboxylesterase 1d (Ces1d) and its human ortholog CES1 have been described to possess lipase activity and play roles in hepatic triacylglycerol metabolism and VLDL assembly. It has been proposed that Ces1d/CES1 might also catalyze cholesteryl ester (CE) hydrolysis in the liver and thus be responsible for the hydrolysis of HDL-derived CE; this could contribute to the final step in the reverse cholesterol transport (RCT) pathway, wherein cholesterol is secreted from the liver into bile and feces, either directly or after conversion to water-soluble bile salts. However, the proposed function of Ces1d/CES1 as a CE hydrolase is controversial. In this study, we interrogated the role hepatic Ces1d plays in cholesterol homeostasis using liver-specific Ces1d-deficient mice. We rationalized that if Ces1d is a major hepatic CE hydrolase, its absence would (1) reduce in vivo RCT flux and (2) provoke liver CE accumulation after a high-cholesterol diet challenge. We found that liver-specific Ces1d-deficient mice did not show any difference in the flux of in vivo HDL-to-feces RCT nor did it cause additional liver CE accumulation after high-fat, high-cholesterol Western-type diet feeding. These findings challenge the importance of Ces1d as a major hepatic CE hydrolase." @default.
• W3175202389 created "2021-07-05" @default.
• W3175202389 creator A5001991964 @default.
• W3175202389 creator A5019036151 @default.
• W3175202389 creator A5026971547 @default.
• W3175202389 creator A5076953535 @default.
• W3175202389 creator A5078336942 @default.
• W3175202389 date "2021-01-01" @default.
• W3175202389 modified "2023-10-05" @default.
• W3175202389 title "Carboxylesterase 1d (Ces1d) does not contribute to cholesteryl ester hydrolysis in the liver" @default.
• W3175202389 cites W1543020414 @default.
• W3175202389 cites W1853601826 @default.
• W3175202389 cites W1921375678 @default.
• W3175202389 cites W1968223239 @default.
• W3175202389 cites W1974922585 @default.
• W3175202389 cites W1978868053 @default.
• W3175202389 cites W1983619827 @default.
• W3175202389 cites W1993473307 @default.
• W3175202389 cites W1993869709 @default.
• W3175202389 cites W2002121467 @default.
• W3175202389 cites W2004462369 @default.
• W3175202389 cites W2022091218 @default.
• W3175202389 cites W2023977281 @default.
• W3175202389 cites W2026852275 @default.
• W3175202389 cites W2027663543 @default.
• W3175202389 cites W2028943130 @default.
• W3175202389 cites W2029085242 @default.
• W3175202389 cites W2030952351 @default.
• W3175202389 cites W2033355598 @default.
• W3175202389 cites W2044218287 @default.
• W3175202389 cites W2064568184 @default.
• W3175202389 cites W2066019571 @default.
• W3175202389 cites W2068458442 @default.
• W3175202389 cites W2073308465 @default.
• W3175202389 cites W2074404717 @default.
• W3175202389 cites W2086038504 @default.
• W3175202389 cites W2099733654 @default.
• W3175202389 cites W2100455028 @default.
• W3175202389 cites W2111528756 @default.
• W3175202389 cites W2112562813 @default.
• W3175202389 cites W2115212312 @default.
• W3175202389 cites W2115904158 @default.
• W3175202389 cites W2117297645 @default.
• W3175202389 cites W2122450058 @default.
• W3175202389 cites W2135007868 @default.
• W3175202389 cites W2136823344 @default.
• W3175202389 cites W2139175950 @default.
• W3175202389 cites W2143805539 @default.
• W3175202389 cites W2147371637 @default.
• W3175202389 cites W2149861331 @default.
• W3175202389 cites W2154869094 @default.
• W3175202389 cites W2155387553 @default.
• W3175202389 cites W2156504663 @default.
• W3175202389 cites W2166812214 @default.
• W3175202389 cites W2167226747 @default.
• W3175202389 cites W2168526937 @default.
• W3175202389 cites W2172179572 @default.
• W3175202389 cites W2314766391 @default.
• W3175202389 cites W2329884988 @default.
• W3175202389 cites W2405936722 @default.
• W3175202389 cites W2732879716 @default.
• W3175202389 cites W2739433436 @default.
• W3175202389 cites W2745669578 @default.
• W3175202389 cites W2784058110 @default.
• W3175202389 cites W2796193474 @default.
• W3175202389 cites W2801420986 @default.
• W3175202389 cites W2825042034 @default.
• W3175202389 cites W2891007226 @default.
• W3175202389 cites W4247935329 @default.
• W3175202389 doi "https://doi.org/10.1016/j.jlr.2021.100093" @default.
• W3175202389 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8287225" @default.
• W3175202389 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34153284" @default.
• W3175202389 hasPublicationYear "2021" @default.
• W3175202389 type Work @default.
• W3175202389 sameAs 3175202389 @default.
• W3175202389 citedByCount "6" @default.
• W3175202389 countsByYear W31752023892021 @default.
• W3175202389 countsByYear W31752023892022 @default.
• W3175202389 countsByYear W31752023892023 @default.
• W3175202389 crossrefType "journal-article" @default.
• W3175202389 hasAuthorship W3175202389A5001991964 @default.
• W3175202389 hasAuthorship W3175202389A5019036151 @default.
• W3175202389 hasAuthorship W3175202389A5026971547 @default.
• W3175202389 hasAuthorship W3175202389A5076953535 @default.
• W3175202389 hasAuthorship W3175202389A5078336942 @default.
• W3175202389 hasBestOaLocation W31752023891 @default.
• W3175202389 hasConcept C110459506 @default.
• W3175202389 hasConcept C126322002 @default.
• W3175202389 hasConcept C134018914 @default.
• W3175202389 hasConcept C150903083 @default.
• W3175202389 hasConcept C178790620 @default.
• W3175202389 hasConcept C181199279 @default.
• W3175202389 hasConcept C185592680 @default.
• W3175202389 hasConcept C207001950 @default.
• W3175202389 hasConcept C2776448209 @default.
• W3175202389 hasConcept C2778163477 @default.
• W3175202389 hasConcept C2778325069 @default.
• W3175202389 hasConcept C2780072125 @default.

• next