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- W3175232553 abstract "Precision diagnostics is one of the two pillars of precision medicine. Sequencing efforts in the past decade have firmly established cancer as a primarily genetically driven disease. This concept is supported by therapeutic successes aimed at particular pathways that are perturbed by specific driver mutations in protein-coding domains and reflected in three recent FDA tissue agnostic cancer drug approvals. In addition, there is increasing evidence from studies that interrogate the entire genome by whole-genome sequencing that acquired global and complex genomic aberrations including those in non-coding regions of the genome might also reflect clinical outcome. After addressing technical, logistical, financial and ethical challenges, national initiatives now aim to introduce clinical whole-genome sequencing into real-world diagnostics as a rational and potentially cost-effective tool for response prediction in cancer and to identify patients who would benefit most from 'expensive' targeted therapies and recruitment into clinical trials. However, so far, this has not been accompanied by a systematic and prospective evaluation of the clinical utility of whole-genome sequencing within clinical trials of uniformly treated patients of defined clinical outcome. This approach would also greatly facilitate novel predictive biomarker discovery and validation, ultimately reducing size and duration of clinical trials and cost of drug development. This manuscript is the third in a series of three to review and critically appraise the potential and challenges of clinical whole-genome sequencing in solid tumors and hematological malignancies." @default.
- W3175232553 created "2021-07-05" @default.
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- W3175232553 date "2022-09-01" @default.
- W3175232553 modified "2023-10-16" @default.
- W3175232553 title "Clinical utility of whole-genome sequencing in precision oncology" @default.
- W3175232553 cites W1495721376 @default.
- W3175232553 cites W1932714322 @default.
- W3175232553 cites W1973154957 @default.
- W3175232553 cites W1979946545 @default.
- W3175232553 cites W2005895632 @default.
- W3175232553 cites W2027246028 @default.
- W3175232553 cites W2039877945 @default.
- W3175232553 cites W2039950956 @default.
- W3175232553 cites W2045021926 @default.
- W3175232553 cites W2061596350 @default.
- W3175232553 cites W2063382533 @default.
- W3175232553 cites W2065377819 @default.
- W3175232553 cites W2082887122 @default.
- W3175232553 cites W2085469565 @default.
- W3175232553 cites W2091168608 @default.
- W3175232553 cites W2093144236 @default.
- W3175232553 cites W2106789440 @default.
- W3175232553 cites W2108371618 @default.
- W3175232553 cites W2136272158 @default.
- W3175232553 cites W2136941319 @default.
- W3175232553 cites W2139216037 @default.
- W3175232553 cites W2150575159 @default.
- W3175232553 cites W2150677022 @default.
- W3175232553 cites W2150757282 @default.
- W3175232553 cites W2167727926 @default.
- W3175232553 cites W2252367299 @default.
- W3175232553 cites W2318605753 @default.
- W3175232553 cites W2344657883 @default.
- W3175232553 cites W2409420104 @default.
- W3175232553 cites W2419140434 @default.
- W3175232553 cites W2503515884 @default.
- W3175232553 cites W2507626327 @default.
- W3175232553 cites W2526188806 @default.
- W3175232553 cites W2554756829 @default.
- W3175232553 cites W2559505355 @default.
- W3175232553 cites W2587175061 @default.
- W3175232553 cites W2588050043 @default.
- W3175232553 cites W2613362156 @default.
- W3175232553 cites W2740523213 @default.
- W3175232553 cites W2740774379 @default.
- W3175232553 cites W2774997518 @default.
- W3175232553 cites W2783595472 @default.
- W3175232553 cites W2787816121 @default.
- W3175232553 cites W2788468983 @default.
- W3175232553 cites W2789924919 @default.
- W3175232553 cites W2797282777 @default.
- W3175232553 cites W2799326392 @default.
- W3175232553 cites W2805911662 @default.
- W3175232553 cites W2806126725 @default.
- W3175232553 cites W2807528614 @default.
- W3175232553 cites W2888045442 @default.
- W3175232553 cites W2889170871 @default.
- W3175232553 cites W2891815860 @default.
- W3175232553 cites W2903833056 @default.
- W3175232553 cites W2907155822 @default.
- W3175232553 cites W2909547032 @default.
- W3175232553 cites W2909798804 @default.
- W3175232553 cites W2911286599 @default.
- W3175232553 cites W2913562638 @default.
- W3175232553 cites W2940308703 @default.
- W3175232553 cites W2943902055 @default.
- W3175232553 cites W2945391001 @default.
- W3175232553 cites W2946104064 @default.
- W3175232553 cites W2966325970 @default.
- W3175232553 cites W2973459418 @default.
- W3175232553 cites W2976525441 @default.
- W3175232553 cites W2977720508 @default.
- W3175232553 cites W2981548686 @default.
- W3175232553 cites W2985901353 @default.
- W3175232553 cites W2986016004 @default.
- W3175232553 cites W2989893822 @default.
- W3175232553 cites W3004480399 @default.
- W3175232553 cites W3008107700 @default.
- W3175232553 cites W3012143751 @default.
- W3175232553 cites W3120668270 @default.
- W3175232553 cites W3134703711 @default.
- W3175232553 cites W4211006558 @default.
- W3175232553 cites W4239818044 @default.
- W3175232553 cites W4244151789 @default.