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• W3175238265 endingPage "110390" @default.
• W3175238265 startingPage "110390" @default.
• W3175238265 abstract "Cocaine dependence is a highly prevalent disease in modern society and lacks an effective treatment. Cannabidiol (CBD), a major non-psychoactive constituent of Cannabis sativa, has been shown to be a promising tool in the management of some neuropsychiatric disorders, including cocaine abuse. However, its therapeutic effects on the behavioral outcomes related to cocaine addiction remain unclear. The present research evaluates the effects of CBD (30, 60 and 120 mg/kg; injected intraperitoneally) on the acquisition, expression, extinction and reinstatement of cocaine (10 mg/kg)-induced conditioned place preference (CPP; Study 1); cocaine (25 mg/kg)-induced locomotor stimulation (Study 2); and cocaine withdrawal symptoms (Study 3) in male C57BL/6 J mice. The results show that CBD does not possess motivational properties in itself and does not modify the acquisition, expression or extinction of cocaine-induced CPP. Interestingly, when administered during the extinction phase of the cocaine-induced CPP, CBD (30 and 60 mg/kg) prevented priming-induced reinstatement of CPP. Moreover, CBD abolished cocaine-induced hyperactivity without altering the spontaneous locomotion of the animals. Furthermore, CBD (120 mg/kg) reduced the memory deficits induced by cocaine withdrawal in the object recognition test, though it did not reverse depressive-like symptoms measured in the tail suspension test. Overall, our data suggest that CBD can prevent the development of cocaine addiction, and, when administered during cocaine abstinence, may be of help in avoiding relapse to drug-seeking and in ameliorating the memory disturbances provoked by chronic consumption of cocaine." @default.
• W3175238265 created "2021-07-05" @default.
• W3175238265 creator A5021106532 @default.
• W3175238265 creator A5022065603 @default.
• W3175238265 creator A5022780571 @default.
• W3175238265 date "2021-12-01" @default.
• W3175238265 modified "2023-10-17" @default.
• W3175238265 title "Cannabidiol prevents several of the behavioral alterations related to cocaine addiction in mice" @default.
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• W3175238265 doi "https://doi.org/10.1016/j.pnpbp.2021.110390" @default.
• W3175238265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34157334" @default.
• W3175238265 hasPublicationYear "2021" @default.
• W3175238265 type Work @default.
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• W3175238265 hasAuthorship W3175238265A5021106532 @default.
• W3175238265 hasAuthorship W3175238265A5022065603 @default.
• W3175238265 hasAuthorship W3175238265A5022780571 @default.

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