FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3175241410> ?p ?o ?g. }

• W3175241410 endingPage "3122" @default.
• W3175241410 startingPage "3122" @default.
• W3175241410 abstract "Liposarcoma (LPS) is an adult soft tissue malignancy that arises from fat tissue, where well-differentiated (WD) and dedifferentiated (DD) forms are the most common. DDLPS represents the progression of WDLPS into a more aggressive high-grade and metastatic form. Although a few DNA copy-number amplifications are known to be specifically found in WD- or DDLPS, systematic genetic differences that signify subtype determination between WDLPS and DDLPS remain unclear. Here, we profiled the genome and transcriptome of 38 LPS tumors to uncover the genetic signatures of subtype differences. Replication-dependent histone (RD-HIST) mRNAs were highly elevated and their regulation was disrupted in a subset of DDLPS, increasing cellular histone molecule levels, as measured using RNA-seq (the averaged fold change of 53 RD-HIST genes between the DD and WD samples was 10.9) and immunohistochemistry. The change was not observed in normal tissues. Integrated whole-exome sequencing, RNA-seq, and methylation analyses revealed that the overexpressed HMGA2 (the fold change between DD and WD samples was 7.3) was responsible for the increased RD-HIST level, leading to aberrant cell proliferation. Therefore, HMGA2-mediated elevation of RD-HISTs were crucial events in determining the aggressiveness of DDLPS, which may serve as a biomarker for prognosis prediction for liposarcoma patients." @default.
• W3175241410 created "2021-07-05" @default.
• W3175241410 creator A5001348492 @default.
• W3175241410 creator A5003412235 @default.
• W3175241410 creator A5018573043 @default.
• W3175241410 creator A5029701997 @default.
• W3175241410 creator A5035401343 @default.
• W3175241410 creator A5039231309 @default.
• W3175241410 creator A5039720718 @default.
• W3175241410 creator A5041602936 @default.
• W3175241410 creator A5053130132 @default.
• W3175241410 creator A5064355894 @default.
• W3175241410 creator A5075118376 @default.
• W3175241410 creator A5080823003 @default.
• W3175241410 creator A5081578294 @default.
• W3175241410 creator A5084012596 @default.
• W3175241410 creator A5087509589 @default.
• W3175241410 creator A5089435906 @default.
• W3175241410 date "2021-06-22" @default.
• W3175241410 modified "2023-10-16" @default.
• W3175241410 title "Overexpression of Replication-Dependent Histone Signifies a Subset of Dedifferentiated Liposarcoma with Increased Aggressiveness" @default.
• W3175241410 cites W1258808631 @default.
• W3175241410 cites W1513529801 @default.
• W3175241410 cites W1976209715 @default.
• W3175241410 cites W1978508787 @default.
• W3175241410 cites W1979411201 @default.
• W3175241410 cites W1986820103 @default.
• W3175241410 cites W2014766736 @default.
• W3175241410 cites W2014929974 @default.
• W3175241410 cites W2020325073 @default.
• W3175241410 cites W2035282314 @default.
• W3175241410 cites W2065530211 @default.
• W3175241410 cites W2067903002 @default.
• W3175241410 cites W2073533521 @default.
• W3175241410 cites W2078964320 @default.
• W3175241410 cites W2086797990 @default.
• W3175241410 cites W2091157137 @default.
• W3175241410 cites W2097065948 @default.
• W3175241410 cites W2102212449 @default.
• W3175241410 cites W2111592257 @default.
• W3175241410 cites W2134526812 @default.
• W3175241410 cites W2169456326 @default.
• W3175241410 cites W2179438025 @default.
• W3175241410 cites W2185118998 @default.
• W3175241410 cites W2316911807 @default.
• W3175241410 cites W2336129655 @default.
• W3175241410 cites W2464814629 @default.
• W3175241410 cites W2765468373 @default.
• W3175241410 cites W2772838698 @default.
• W3175241410 cites W2790704518 @default.
• W3175241410 cites W2794480084 @default.
• W3175241410 cites W2794530843 @default.
• W3175241410 cites W2796217370 @default.
• W3175241410 cites W2920631851 @default.
• W3175241410 cites W2943815170 @default.
• W3175241410 cites W2995570957 @default.
• W3175241410 doi "https://doi.org/10.3390/cancers13133122" @default.
• W3175241410 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8269115" @default.
• W3175241410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34206586" @default.
• W3175241410 hasPublicationYear "2021" @default.
• W3175241410 type Work @default.
• W3175241410 sameAs 3175241410 @default.
• W3175241410 citedByCount "5" @default.
• W3175241410 countsByYear W31752414102022 @default.
• W3175241410 countsByYear W31752414102023 @default.
• W3175241410 crossrefType "journal-article" @default.
• W3175241410 hasAuthorship W3175241410A5001348492 @default.
• W3175241410 hasAuthorship W3175241410A5003412235 @default.
• W3175241410 hasAuthorship W3175241410A5018573043 @default.
• W3175241410 hasAuthorship W3175241410A5029701997 @default.
• W3175241410 hasAuthorship W3175241410A5035401343 @default.
• W3175241410 hasAuthorship W3175241410A5039231309 @default.
• W3175241410 hasAuthorship W3175241410A5039720718 @default.
• W3175241410 hasAuthorship W3175241410A5041602936 @default.
• W3175241410 hasAuthorship W3175241410A5053130132 @default.
• W3175241410 hasAuthorship W3175241410A5064355894 @default.
• W3175241410 hasAuthorship W3175241410A5075118376 @default.
• W3175241410 hasAuthorship W3175241410A5080823003 @default.
• W3175241410 hasAuthorship W3175241410A5081578294 @default.
• W3175241410 hasAuthorship W3175241410A5084012596 @default.
• W3175241410 hasAuthorship W3175241410A5087509589 @default.
• W3175241410 hasAuthorship W3175241410A5089435906 @default.
• W3175241410 hasBestOaLocation W31752414101 @default.
• W3175241410 hasConcept C104317684 @default.
• W3175241410 hasConcept C142724271 @default.
• W3175241410 hasConcept C150194340 @default.
• W3175241410 hasConcept C153911025 @default.
• W3175241410 hasConcept C162317418 @default.
• W3175241410 hasConcept C173396325 @default.
• W3175241410 hasConcept C190727270 @default.
• W3175241410 hasConcept C2778256501 @default.
• W3175241410 hasConcept C2779568860 @default.
• W3175241410 hasConcept C2781197716 @default.
• W3175241410 hasConcept C502942594 @default.
• W3175241410 hasConcept C54355233 @default.
• W3175241410 hasConcept C64927066 @default.
• W3175241410 hasConcept C71924100 @default.
• W3175241410 hasConcept C86803240 @default.

• next