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- W3175242783 abstract "Comparative analysis of microarrays data from intestine of sexually immature “yellow” eels and sexually mature “silver” eels revealed the differential expression of a novel member of the phospholipase C (PLC) family, known as PLCX-domain containing protein (PLCXD), which has unknown function. We investigated the expression of the PLCXD gene in eel, zebrafish and human. The expression of three human PLCXD isoforms known as -XD1, -XD2 and –XD3 have been characterised in tissues and cultured cell lines. The proteins exhibit differential cellular location (when expressed in HeLa cells) suggesting different functions. PLCXD1 is expressed in perinuclear vesicles, -XD2 in the nucleus, and –XD3 in the cytoplasm. In zebrafish we identified five PLCXD isoforms. The eel PLCXD protein shares maximum of similarity (51%) with zfPLCXD4 and only around 40% with all hPLCXDs. In contrast, zfPLCXD1, 2, and 3 orthologues share 65%, 68%, and 93% aa. homology with the human equivalents. Zebrafish and human PLCXD gene isoforms show similar tissue expression. For example, all are expressed in the brain and PLCXD3 is mostly expressed in heart. There is also difference in gene expression between species, eg. the highest level of eel PLCXD expression is in intestine, but the equivalent homologue in zebrafish is mainly in the head kidney. Our studies indicate different functional roles of PLCXD proteins during evolution." @default.
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- W3175242783 date "2012-04-01" @default.
- W3175242783 modified "2023-09-25" @default.
- W3175242783 title "Expression of gene isoforms encoding phospholipase C X‐domain containing proteins in fish and humans" @default.
- W3175242783 doi "https://doi.org/10.1096/fasebj.26.1_supplement.1064.15" @default.
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