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- W3175254017 abstract "Drosha initiates the production of miRNAs from precursors. To study the functions of miRNA in adrenal steroid production, we knocked down Drosha expression in the HAC15 cell, a subclone of the H295R human adrenocortical cell, using lentiviral vectors to deliver shRNA of Drosha. Drosha protein levels in the infected HAC15 cells were reduced by 74.3% compared to empty vector infected control cells. Drosha knock-down led to 36.3% and 46.4% suppression of aldosterone production under basal and after angiotensin II (A-II) stimulated conditions, respectively. Basal and A-II stimulated StAR and HSD3B2 mRNA expression levels in the Drosha knock-down cells were also significantly suppressed; expression of other enzymes required for aldosterone synthesis were not altered. In conclusion, suppression of Drosha significantly diminished basal and A-II stimulated StAR and HSD3B2 mRNA expression and aldosterone production, suggesting that at least one miRNA is essential for aldosterone production. Support: VA Medical Research Funds, NIH HL27255 & HL75321" @default.
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- W3175254017 date "2012-04-01" @default.
- W3175254017 modified "2023-09-27" @default.
- W3175254017 title "Drosha‐dependent miRNA regulate aldosterone synthesis by increasing StAR and HSD3B2 expression" @default.
- W3175254017 doi "https://doi.org/10.1096/fasebj.26.1_supplement.1093.14" @default.
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