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- W3175262616 endingPage "6754" @default.
- W3175262616 startingPage "6754" @default.
- W3175262616 abstract "The emergence of fungal “superbugs” resistant to the limited cohort of anti-fungal agents available to clinicians is eroding our ability to effectively treat infections by these virulent pathogens. As the threat of fungal infection is escalating worldwide, this dwindling response capacity is fueling concerns of impending global health emergencies. These developments underscore the urgent need for new classes of anti-fungal drugs and, therefore, the identification of new targets. Phosphoinositide signaling does not immediately appear to offer attractive targets due to its evolutionary conservation across the Eukaryota. However, recent evidence argues otherwise. Herein, we discuss the evidence identifying Sec14-like phosphatidylinositol transfer proteins (PITPs) as unexplored portals through which phosphoinositide signaling in virulent fungi can be chemically disrupted with exquisite selectivity. Recent identification of lead compounds that target fungal Sec14 proteins, derived from several distinct chemical scaffolds, reveals exciting inroads into the rational design of next generation Sec14 inhibitors. Development of appropriately refined next generation Sec14-directed inhibitors promises to expand the chemical weaponry available for deployment in the shifting field of engagement between fungal pathogens and their human hosts." @default.
- W3175262616 created "2021-07-05" @default.
- W3175262616 creator A5001668796 @default.
- W3175262616 creator A5022522725 @default.
- W3175262616 creator A5044444045 @default.
- W3175262616 creator A5085155459 @default.
- W3175262616 date "2021-06-23" @default.
- W3175262616 modified "2023-10-01" @default.
- W3175262616 title "Emerging Prospects for Combating Fungal Infections by Targeting Phosphatidylinositol Transfer Proteins" @default.
- W3175262616 cites W1042686957 @default.
- W3175262616 cites W1481998649 @default.
- W3175262616 cites W178269644 @default.
- W3175262616 cites W1817988031 @default.
- W3175262616 cites W1868830645 @default.
- W3175262616 cites W1954570499 @default.
- W3175262616 cites W1964881184 @default.
- W3175262616 cites W1970142332 @default.
- W3175262616 cites W1970485485 @default.
- W3175262616 cites W1972044172 @default.
- W3175262616 cites W1972502085 @default.
- W3175262616 cites W1972665490 @default.
- W3175262616 cites W1977267009 @default.
- W3175262616 cites W1977889337 @default.
- W3175262616 cites W1979104861 @default.
- W3175262616 cites W1979348380 @default.
- W3175262616 cites W1981202925 @default.
- W3175262616 cites W1986267127 @default.
- W3175262616 cites W1987095367 @default.
- W3175262616 cites W1987640473 @default.
- W3175262616 cites W1992030675 @default.
- W3175262616 cites W1992111809 @default.
- W3175262616 cites W1994803385 @default.
- W3175262616 cites W2002194264 @default.
- W3175262616 cites W2002341882 @default.
- W3175262616 cites W2005445415 @default.
- W3175262616 cites W2015140940 @default.
- W3175262616 cites W2023518810 @default.
- W3175262616 cites W2028219068 @default.
- W3175262616 cites W2029354255 @default.
- W3175262616 cites W2030855526 @default.
- W3175262616 cites W2031410708 @default.
- W3175262616 cites W2032581399 @default.
- W3175262616 cites W2036047219 @default.
- W3175262616 cites W2037490208 @default.
- W3175262616 cites W2037668562 @default.
- W3175262616 cites W2042565484 @default.
- W3175262616 cites W2042655557 @default.
- W3175262616 cites W2049069193 @default.
- W3175262616 cites W2049144892 @default.
- W3175262616 cites W2050290299 @default.
- W3175262616 cites W2050621406 @default.
- W3175262616 cites W2054617705 @default.
- W3175262616 cites W2055593282 @default.
- W3175262616 cites W2058706417 @default.
- W3175262616 cites W2059637730 @default.
- W3175262616 cites W2061655086 @default.
- W3175262616 cites W2061894085 @default.
- W3175262616 cites W2064892346 @default.
- W3175262616 cites W2065711215 @default.
- W3175262616 cites W2077088073 @default.
- W3175262616 cites W2079764502 @default.
- W3175262616 cites W2080865232 @default.
- W3175262616 cites W2085808820 @default.
- W3175262616 cites W2088696121 @default.
- W3175262616 cites W2090486711 @default.
- W3175262616 cites W2091061873 @default.
- W3175262616 cites W2093160716 @default.
- W3175262616 cites W2100138389 @default.
- W3175262616 cites W2100626246 @default.
- W3175262616 cites W2101011391 @default.
- W3175262616 cites W2101938296 @default.
- W3175262616 cites W2102737995 @default.
- W3175262616 cites W2104256906 @default.
- W3175262616 cites W2106522725 @default.
- W3175262616 cites W2107794472 @default.
- W3175262616 cites W2108491966 @default.
- W3175262616 cites W2109480104 @default.
- W3175262616 cites W2111448805 @default.
- W3175262616 cites W2112005645 @default.
- W3175262616 cites W2112662538 @default.
- W3175262616 cites W2113427739 @default.
- W3175262616 cites W2113522006 @default.
- W3175262616 cites W2114798009 @default.
- W3175262616 cites W2117022661 @default.
- W3175262616 cites W2118532162 @default.
- W3175262616 cites W2119318973 @default.
- W3175262616 cites W2119919876 @default.
- W3175262616 cites W2120540699 @default.
- W3175262616 cites W2124259255 @default.
- W3175262616 cites W2124804382 @default.
- W3175262616 cites W2126736952 @default.
- W3175262616 cites W2128982869 @default.
- W3175262616 cites W2130698990 @default.
- W3175262616 cites W2131821856 @default.
- W3175262616 cites W2131917705 @default.
- W3175262616 cites W2134282732 @default.
- W3175262616 cites W2136643380 @default.
- W3175262616 cites W2139732273 @default.